Química Inorgànica i Orgànica: Enviaments recents
Ara mostrant els elements 301-320 de 1012
Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data
We present Farseer-NMR (https ://git.io/vAueU), a software package to treat, evaluate and combine NMR spectroscopic data from sets of protein-derived peaklists covering a range of experimental conditions. The combined ...
Insights into the Spin Dynamics of Mononuclear Cerium(III) Single-Molecule Magnets
Four novel CeIII mononuclear complexes of formulas [Ce(ntfa)3(MeOH)2] (1), [Ce(ntfa)3(5,5′-Me2bipy)] (2), [Ce(ntfa)3(terpy)] (3), and [Ce(ntfa)3(bipy)2] (4), where ntfa = 4,4,4-trifluoro-1-(naphthalen-2-yl)butane-1,3-dionato, ...
Co(II) and Cu(II) fluorescent complexes with acridine based ligands
The condensation reaction of salicylaldehyde or 2‐hydroxynaphthaldehyde with a diamino organic group (Acridine Yellow or diaminoacridine) resulted in the Schiff‐base ligands ACRI‐1, ACRI‐2 and ACRI‐3, with the last two ...
Tm(III) complexes undergoing slow relaxation of magnetization: exchange coupling and aging effects
The present study focuses on the dynamical magnetic behaviour of exchange coupled 3d-4f complexes containing the scarcely considered non Kramers Tm3+ center, the 3d metal ions being either the low-spin Fe3+ (1) or the ...
SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules
Antiviral agents are needed for the treatment of SARS-CoV-2 infections and to control other coronavirus outbreaks that may occur in the future. Here we report the identification and characterization of RNA-binding compounds ...
Investigating the Impact of Packing and Environmental Factors on the Luminescence of Pt(N^N^N) Chromophores
Es van sintetitzar quatre compostos Pt(II)(N^N^N) amb coordinació de DMSO en la quarta posició. Els lligands variaven pel que fa al nucli central de piridil (substituents d'hidrogen o clor) i els anells laterals (triazols ...
Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer
The metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with ...
Novel Topologies in Vanadium-bis-β-Diketone Chemistry: A [V4] and a [V6] Metallacyclophane
Exploring the chemistry of vanadyl ions (VO2+) with bis-β-diketone ligands, in pyridine reactions of vanadyl sulfate with 1,3-bis-(3-oxo-3-(2-hydroxyphenyl)-propionyl)-benzene (H4L1) and 1,3-bis-(3-oxo-3-(2-hydroxyphenyl ...
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide- processing functions of ferredoxin-2 and frataxin
Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects lead to severe diseases among which is Friedreich's ataxia caused by impaired expression of frataxin (FXN). Fe-S clusters are biosynthesized ...
Structural Characterization, Magnetic and Luminescent Properties of Praseodymium(III)‐4,4,4‐Trifluoro‐1‐(2‐Naphthyl)Butane‐1,3‐Dionato(1‐)Complexes
Four new Pr(III) mononuclear complexes of formula [Pr(ntfa)3(MeOH)2] (1), [Pr(ntfa)3(bipy)2] (2), [Pr(ntfa)3(4,4′-Mt2bipy)] (3) and [Pr(ntfa)3(5,5′-Me2bipy)] (4), where ntfa = 4,4,4-trifuoro-1-(naphthalen-2-yl)butane-1,3 ...
Nanotechnological approaches to address photosensitizers' limitations: towards improved clinical applicability of photodynamic therapy
Photodynamic therapy (PDT) uses a combination of molecular oxygen, light and a photosensitizer (PS) to generate singlet oxygen or reactive oxygen species (ROS), which can eradicate tumoral cells. All currently approved PSs ...
Supported -Complexes of LiC Bonds from Coordination of Monomeric Molecules of LiCH3, LiCH2CH3 and LiC6H5 to MoMo Bonds
LiCH3 and LiCH2CH3 react with the complex [Mo2(H)2(μ-AdDipp2)2(thf)2] (1⋅thf) with coordination of two molecules of LiCH2R (R=H, CH3) and formation of complexes [Mo2{μ-HLi(thf)CH2R}2(AdDipp2)2], 5⋅LiCH3 and 5⋅LiCH2CH3, ...
Novel uranyl(VI) complexes incorporating ethynyl groups as potential halide chemosensors: an experimental and computational approach
The synthesis of two novel Uranyl-salophen complexes, 1 and 2, decorated with ethynyl substituents, and the study in chloroform of their binding properties toward three different tetrabutylammonium halide salts, i.e. ...
Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines
An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over ...
BMS Derivatives C7-Linked to β-Cyclodextrin and Hyperbranched Polyglycerol Retain Activity against R5-HIV-1NLAD8 Isolates and Can Be Deemed Potential Microbicides
Amides from indole-3-glyoxylic acid and 4-benzoyl-2-methylpiperazine,which are related to entry inhibitors developed by Bristol-MyersSquibb (BMS), have been synthesized with aliphatic chains located at the C7 position of ...
Bifunctional tripeptide with a phosphonic acid as a bronsted acid for Michael addition: mechanistic insights
Enamine catalysis is a widespread activation mode in the field of organocatalysis and is often encountered in bifunctional organocatalysts. We previously described H-Pro-Pro-pAla-OMe as a bifunctional catalyst for Michael ...
Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates
Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related ...
Redox shield enfolding a magnetic core
Ferrocenyl betadiketones were reacted with hydrated lanthanide trihalides in presence of a base to yield red color solids, whose structures were characterized by single crystal X-ray diffraction technique. Structural ...
(Z)-Oxopropene-1,3-diyl, a linker for the conjugation of the thiol group of cysteine with amino-derivatized drugs
We have developed a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be an alternative to maleimides, the most commonly used reagents to link thiol groups (of Cys) to drugs and ...
P-Stereogenic Ir-MaxPHOX: A Step toward Privileged Catalysts for Asymmetric Hydrogenation of Nonchelating Olefins
The Ir-MaxPHOX-type catalysts demonstrated high catalytic performance in the hydrogenation of a wide range of nonchelating olefins with different geometries, substitution patterns, and degrees of functionalization. These ...
