Química Inorgànica i Orgànica: Recent submissions
Now showing items 41-60 of 1012
Three lanthanide complexes with mixed salicylate and 1,10-phenanthroline: syntheses, crystal structures, and luminescent/magnetic properties
Three new lanthanide complexes incorporating salicylate (HSA or SA) and 1,10-phenanthroline (phen), Ln(3)(HSA)(5)(SA)(2)(phen)(3) [Ln=Ho (1) and Er (2)], and Sm-2(HSA)(2)(SA)(2)(phen)(3) (3), have been synthesized. X-ray ...
Selective signalling of alcohols by a molecular lattice and mechanism of single-crystal-to-single-crystal transformations
Single-crystal-to-single-crystal (SCSC) transformations of molecular materials involving exchange of lattice molecules are becoming commonplace and very relevant in areas like chemical sensing or the pharmaceutical sector. ...
Exploring the Phototherapeutic Applications of Mitochondria-Targeted COUPY Photocages of Antitumor Drugs
Photocleavable protecting groups hold great promise in photopharmacology to control the release of bioactive molecules from their caged precursors within specific subcellular compartments. Herein, we describe a series of ...
Direct, enantioselective, and nickel(II) catalyzed reactions of N-azidoacetyl thioimides with trimethyl orthoformate: a new combined methodology for the rapid synthesis of lacosamide and derivatives
A direct and highly enantioselective reaction of N-azidoacetyl-1,3-thiazolidine-2-thione with trimethyl orthoformate catalyzed by Tol-BINAPNiCl2 in the presence of TESOTf and 2,6-lutidine is reported. The heterocyclic ...
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells
Ovarian cancer (OC) is caused by genetic aberrations in networks that control growth and survival. Importantly, aberrant cancer metabolism interacts with oncogenic signaling providing additional drug targets. Tumors ...
Lanthanide chain assembled in metal-organic frameworks: slow relaxation of the magnetization in Dy (III) and Er (III) complexes
Three new LnIII-MOFs, {[Dy1.5(TAPB)1.5(DMF)]·9DMF}n (Ln = Dy (1), Er (2), Ho (3); TAPB = 4, 4′, 4″-(triazine‑2, 4, 6‑triyl‑tris‑(benzene‑4, 1-diyl)) tribenzoate), have been synthesized via a solvothermal method by using a ...
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
We report the design of hetero-bifunctional small molecules that selectively target p38α and p38β for degradation. These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, ...
Aggregation of gold(I) complexes: phosphorescence vs. singlet oxygen production
Herein we report on the synthesis of six new phosphane-gold(I)-4-ethynylaniline complexes (neutral and cationic), with a tris-naphthalene substituted tertiary phosphane bearing a secondary amine as a linker and containing ...
Single-molecule transport of fullerene-based curcuminoids
We present experimental and theoretical studies of single-molecule conductance through nonplanar fullerocurcuminoid molecular dyads in ambient conditions using the mechanically controllable break junction technique. We ...
Strengthened cooperativity of DNA-based cyclic hydrogen-bonded rosettes by subtle functionalization
Cooperative effects cause extra stabilization of hydrogen-bonded supramolecular systems. In this work we have designed hydrogen-bonded rosettes derived from a guanine–cytosine Janus-type motif with the aim of finding a ...
Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of ...
Direct evidence of a graded magnetic interface in bi-magnetic core/shell nanoparticles using electron magnetic circular dichroism (e-MCD).
nterfaces play a crucial role in composite magnetic materials and particularly in bimagnetic core/shell nanoparticles. However, resolving the microscopic magnetic structure of these nanoparticles is rather complex. Here, ...
Structure of the Reduced Copper Active Site in Pre-Processed Galactose Oxidase: Ligand Tuning for One-Electron O2 Activation in Cofactor Biogenesis
Galactose oxidase (GO) is a copper-dependent enzyme that accomplishes 2e- substrate oxidation by pairing a single copper with an unusual cysteinylated tyrosine (Cys-Tyr) redox cofactor. Previous studies have demonstrated ...
Co/Fe(alpha-Alkyl-tpdt)(2) (x-): Alkyl-Substituted Cobalt and Iron Bis-dithiolenethiophenic Complexes
Tetraphenylphosphonium salts of Co and Fe complexes with alkyl substituted, tert-butyl (tb) and isopropyl (dp), 2,3-thiophenedithiolate (α-tpdt) ligands, namely TPP[Co(α-tb-tpdt)2] (3), TPP2[Fe(α-tb-tpdt)2]2 (4a-b), ...
The Biomolecules Journal Club: Highlights on Recent Papers 1
We are glad to share with you our first Journal Club and to highlight some of the most interesting papers published recently. We hope we will tease your curiosity and encourage you to read full papers outside of your ...
A New Cyclometalation Motif: Synthesis, Characterization, Structures, and Reactivity of Pallada- and Platinacycles with a Bidentate {C(sp2,cyrhetrene),N}− Ligand
The synthesis, characterization, X-ray crystal structure, and study of the reactivity of the novel cyretrenyl ligand [{(η5-C5H4-2-C5H4N)}Re(CO)3 (1) with Pd(OAc)2 or [MCl2(DMSO)2] (M = Pd, Pt) are reported. These studies ...
Identification of Antimicrobial Peptides in Flowers of Sambucus Nigra
The elder (Sambucus spp.) tree has a number of uses in traditional medicine. Previous studies have demonstrated the antimicrobial properties of elderberry liquid extract against human pathogenic bacteria and also influenza ...
NMR signal enhancement of > 50 000 times in fast dissolution dynamic nuclear polarization
Herein, we report the synthesis and the study of a novel mixed biradical with BDPA and TEMPO radical units that are covalently bound by an ester group (BDPAesterTEMPO) as a polarizing agent for fast dissolution DNP. The ...
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling energy balance
Targeting brain lipid metabolism is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity. The development of stable platforms for selective delivery of drugs, particularly to the ...
Diarylplatinum(II) compounds as versatile metallating agents in the synthesis of cyclometallated platinum compounds with N-donor ligands
This review deals with the reactions of diarylplatinum(II) complexes with N-donor ligands to produce a variety of cycloplatinated compounds including endo-five-, endo-seven-, endo-six- or exo-five-membered platinacycles. ...
