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| Título: | Identification of c.483C>T polymorphism in the caprine Tyrosinase-related protein 1(TYRP1) gene |
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| Autor/a: | Badaoui, Bouabid; Manunza, Arianna; D'Andrea, Mariasilvia; Pilla, Fabio; Capote, Juan; Jordana i Vidal, Jordi; Ferrando, Ainhoa; Martinez, Amparo; Delgado Bermejo, Juan Vicente; Landi, Vincenzo; Gómez, Mariano; Pons Barro, Agueda L.; El-Ouni, Mabrouk; Vidal i Fàbrega, Oriol; Amills i Eras, Marcel |
| Abstract: | Tyrosinase-related protein 1 (TYRP1) has been shown to play a fundamental role in pigmentation both in human and mouse. In this work, we aimed to characterize the variability of the caprine TYRP1 gene and investigate its segregation in a wide array of goat breeds. By partially sequencing the coding region of the TYRP1 gene in 18 individuals from eight different breeds, we were able to identify a synonymous nucleotide substitution at exon 3 (c.483C>T). An extensive survey of Iberian and Balearic (N=175), Italian (N=99), Swiss (N=54), Asian (N=14), Canarian (N=92) and North African (N=117) goats with different coat colours was carried out. We found that the C-allele has a different distribution in European vs African breeds, being almost fixed in the latter. Moreover, the C-allele showed an increased frequency in white coated breeds (Girgentana, Grigia Molisana, Blanca de Rasquera and Saanen) when compared with those displaying a dark pigmentation (Cilentana Nera, Azpi Gorri and Murciano-Granadina). This could be due to genetic drift, migration and other factors associated with the demographic history of breeds under analysis or to a genetic hitchhiking event (c.483C>T frequencies would be shaped by a neighbouring causal mutation differentially selected in white and black goats). More refined studies will be needed to distinguish between these two alternative explanations. |
| Materia(s): | -Coat colour -Goat -Tyrosinase-related protein 1 |
| Derechos: | open access
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| Tipo de documento: | Article |
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| Uri: | https://ddd.uab.cat/record/204421 |
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