dc.contributor.author |
Badaoui, Bouabid |
dc.contributor.author |
Manunza, Arianna |
dc.contributor.author |
D'Andrea, Mariasilvia |
dc.contributor.author |
Pilla, Fabio |
dc.contributor.author |
Capote, Juan |
dc.contributor.author |
Jordana i Vidal, Jordi |
dc.contributor.author |
Ferrando, Ainhoa |
dc.contributor.author |
Martinez, Amparo |
dc.contributor.author |
Delgado Bermejo, Juan Vicente |
dc.contributor.author |
Landi, Vincenzo |
dc.contributor.author |
Gómez, Mariano |
dc.contributor.author |
Pons Barro, Agueda L. |
dc.contributor.author |
El-Ouni, Mabrouk |
dc.contributor.author |
Vidal i Fàbrega, Oriol |
dc.contributor.author |
Amills i Eras, Marcel |
dc.date |
2012 |
dc.identifier |
https://ddd.uab.cat/record/204421 |
dc.identifier |
urn:10.4081/ijas.2012.e12 |
dc.identifier |
urn:oai:ddd.uab.cat:204421 |
dc.identifier |
urn:recercauab:ARE-66867 |
dc.identifier |
urn:scopus_id:84863635960 |
dc.identifier |
urn:articleid:15944077v11n1p63 |
dc.identifier |
urn:wos_id:000303982800012 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/a9219581-cf9b-4e89-a668-5547cec02da6 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Italian Journal of Animal Science ; Vol. 11, art. e12 (2012), p. 63-67 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Coat colour |
dc.subject |
Goat |
dc.subject |
Tyrosinase-related protein 1 |
dc.title |
Identification of c.483C>T polymorphism in the caprine Tyrosinase-related protein 1(TYRP1) gene |
dc.type |
Article |
dc.description.abstract |
Tyrosinase-related protein 1 (TYRP1) has been shown to play a fundamental role in pigmentation both in human and mouse. In this work, we aimed to characterize the variability of the caprine TYRP1 gene and investigate its segregation in a wide array of goat breeds. By partially sequencing the coding region of the TYRP1 gene in 18 individuals from eight different breeds, we were able to identify a synonymous nucleotide substitution at exon 3 (c.483C>T). An extensive survey of Iberian and Balearic (N=175), Italian (N=99), Swiss (N=54), Asian (N=14), Canarian (N=92) and North African (N=117) goats with different coat colours was carried out. We found that the C-allele has a different distribution in European vs African breeds, being almost fixed in the latter. Moreover, the C-allele showed an increased frequency in white coated breeds (Girgentana, Grigia Molisana, Blanca de Rasquera and Saanen) when compared with those displaying a dark pigmentation (Cilentana Nera, Azpi Gorri and Murciano-Granadina). This could be due to genetic drift, migration and other factors associated with the demographic history of breeds under analysis or to a genetic hitchhiking event (c.483C>T frequencies would be shaped by a neighbouring causal mutation differentially selected in white and black goats). More refined studies will be needed to distinguish between these two alternative explanations. |