| dc.contributor.author | Pañella, Clara |
|---|---|
| dc.contributor.author | Moll Sánchez, Xavier |
| dc.contributor.author | Quesada, Rita |
| dc.contributor.author | Villanueva Garatachea, Alberto |
| dc.contributor.author | Iglesias, Mar |
| dc.contributor.author | Andaluz Martínez, Anna |
| dc.contributor.author | Lucía, O. |
| dc.contributor.author | Sánchez-Velázquez, Patricia |
| dc.contributor.author | Grande, L |
| dc.contributor.author | Burdío, Fernando |
| dc.date | 2019 |
| dc.identifier | https://ddd.uab.cat/record/220398 |
| dc.identifier | urn:oai:ddd.uab.cat:220398 |
| dc.description.abstract | Introduction: Irreversible Electroporation (IRE) is highly dependent on the electrical conductivity of the tissue and the high conductivity of tumor tissue, which leads to a lower field than in the surrounding healthy tissue. Hypersaline Infusion (HI) through the portal vein focuses IRE on scattered liver tumors, by creating a differential conductivity between the different types of tissue. The aim of this study is to determine the effects of the HI protocol on the hepatic and histological biochemical results. Methods: Ten male Sprague Dawley rats were used for HI protocol. Blood samples were collected at pre-, immediately post-, 24-hrs, 72-hrs, 1-week and 3-weeks post-HI. All the animals were sacrificed after one-month follow-up in order to collect histological samples. Results: The mortality rate in this procedure reached 30% (3/10). Only the pH and transaminases at 24-hrs were significantly and directly linked to mortality (p=0.036 and p=0.004, respectively). The three non-surviving animals had a four-time higher AST level at 24-hrs. Natremia normalized at 24-hrs post-HI. Statistically significant differences were found in hepatic necrosis between the non-surviving (n=3) and surviving rats (n=7) (30.67 ± 10.97 vs. 2.86 ± 7.56% respectively, p=0.01). Discussion: HI through the portal system involves a significant risk of possibly lethal cytolysis and acidosis. Therefore, compensatory measures and a reduced saline overload are warranted to improve the survival rates. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | |
| dc.relation | Ministerio de Ciencia e Innovación TEC2014-52383-C3-R |
| dc.relation | Clinics in Surgery ; Núm. 4 (2019) |
| dc.rights | open access |
| dc.rights | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ |
| dc.subject | Electroporació |
| dc.subject | Cirurgia |
| dc.title | Hypersaline Infusion Protocol through the Portal Vein may Focus Electroporation on Tumor Tissue, but is it really Safe? Preliminary Results |
| dc.type | Article |
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