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| dc.contributor.author | Martínez Cengotitabengoa, Mónica |
|---|---|
| dc.contributor.author | MacDowell, Karina S. |
| dc.contributor.author | Alberich, Susana |
| dc.contributor.author | Díaz, FJ. |
| dc.contributor.author | García-Bueno, Borja |
| dc.contributor.author | Rodriguez Jimenez, Roberto |
| dc.contributor.author | Bioque Alcázar, Miquel |
| dc.contributor.author | Berrocoso, Esther |
| dc.contributor.author | Parellada, Mara |
| dc.contributor.author | Lobo, Antonio |
| dc.contributor.author | Saiz, Pilar A. |
| dc.contributor.author | Matute, Carlos |
| dc.contributor.author | Bernardo Arroyo, Miquel |
| dc.contributor.author | González-Pinto, Ana |
| dc.contributor.author | Leza, Juan Carlos |
| dc.date | 2017-10-23T13:32:32Z |
| dc.date | 2017-10-23T13:32:32Z |
| dc.date | 2015-06-30 |
| dc.date | 2017-10-23T13:32:32Z |
| dc.identifier | 0586-7614 |
| dc.identifier | 654433 |
| dc.identifier | 26130821 |
| dc.identifier.uri | http://hdl.handle.net/2445/116933 |
| dc.description | Previous studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs |
| dc.format | 10 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Oxford University Press |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1093/schbul/sbv078 |
| dc.relation | Schizophrenia Bulletin, 2015, vol. 42, num. 1, p. 142-151 |
| dc.relation | https://doi.org/10.1093/schbul/sbv078 |
| dc.rights | cc-by-nc-nd (c) Martínez-Cengotitabengoa, Mónica et al., 2015 |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Psicosi |
| dc.subject | Trastorns afectius |
| dc.subject | Antipsicòtics |
| dc.subject | Farmacologia |
| dc.subject | Estudi de casos |
| dc.subject | Inflamació |
| dc.subject | Psychoses |
| dc.subject | Affective disorders |
| dc.subject | Antipsychotic drugs |
| dc.subject | Pharmacology |
| dc.subject | Case studies |
| dc.subject | Inflammation |
| dc.title | BDNF and NGF signalling in early phases of psychosis: relationship with inflammation and response to antipsychotics after a 1 year |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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