Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease

Home | About RECERCAT | Contact

Català | Castellano

All of RECERCAT

By Communities &
Collections By Defense Date By Authors By Titles By Subject

This Collection

By Defense Date By Authors By Titles By Subject

Statistics

View Statistics All RECERCAT

My RECERCAT

Other repositories directory

RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/121780

dc.contributor.author	Paul, Tanja
dc.contributor.author	Salazar-Degracia, Anna
dc.contributor.author	Peinado Cabré, Víctor Ivo
dc.contributor.author	Tura-Ceide, Olga
dc.contributor.author	Blanco Vich, Isabel
dc.contributor.author	Barreiro, Esther
dc.contributor.author	Barberà i Mir, Joan Albert
dc.date	2018-04-23T13:15:45Z
dc.date	2018-04-23T13:15:45Z
dc.date	2018-01-05
dc.date	2018-04-23T13:15:45Z
dc.identifier	1932-6203
dc.identifier	679139
dc.identifier	29304131
dc.identifier.uri	http://hdl.handle.net/2445/121780
dc.description	Objective Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3′,5′-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the effects of sGC stimulation on oxidative stress in the plasma of guinea pigs chronically exposed to cigarette smoke (CS). Methods and results Guinea pigs were exposed to CS or sham for three months, and received either the sGC stimulator BAY 41-2272 or vehicle. Body weight was measured weekly; and markers of oxidative stress in plasma, and airspace size and inflammatory cell infiltrate in lung tissue were analyzed at the end of the study. Compared to sham-exposed guinea pigs, CS-exposed animals gained less body weight and showed higher plasma levels of nitrated tyrosine residues (3-NT), 4-hydroxynonenal (4-HNE), and 8-hydroxydeoxyguanosine (8-OHdG). Treatment with the sGC stimulator led to a body weight gain in the CS-exposed guinea pigs similar to non-exposed and attenuated the increase in 3-NT and 4-HNE. Plasma levels of 3-NT correlated with the severity of inflammatory cell infiltrate in the lung. Conclusion Stimulation of sGC prevents oxidative stress induced by CS exposure and is associated with an attenuated inflammatory response in the lung.
dc.format	application/pdf
dc.language	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation	Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0190628
dc.relation	PLoS One, 2018, vol. 13, num. 1, p. e0190628
dc.relation	https://doi.org/10.1371/journal.pone.0190628
dc.rights	cc-by (c) Paul, Tanja et al., 2018
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Malalties de l'aparell respiratori
dc.subject	Medicaments
dc.subject	Respiratory organs diseases
dc.subject	Drugs
dc.title	Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

Show simple item record

All of RECERCAT

This Collection

Statistics

My RECERCAT

Related documents

Other documents of the same author