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Título:	Altered cortical development in fetuses with isolated nonsevere ventriculomegaly assessed by neurosonography
Autor/a:	Hahner, Nadine; Puerto Navarro, Bienvenido; Pérez-Cruz, Miriam; Policiano, Catarina; Monterde, Elena; Crispi Brillas, Fàtima; Gratacós Solsona, Eduard; Eixarch Roca, Elisenda
Notas:	OBJECTIVES: To perform a comprehensive assessment of cortical development in fetuses with isolated nonsevere ventriculomegaly (INSVM) by neurosonography. METHODS: We prospectively included 40 fetuses with INSVM and 40 controls. INSVM was defined as atrial width between 10.0 and 14.9 mm without associated malformation, infection, or chromosomal abnormality. Cortical development was assessed by neurosonography at 26 and 30 weeks of gestation measuring depth of selected sulci and applying a maturation scale from 0 (no appearance) to 5 (maximally developed) of main sulci and areas. RESULTS: INSVM showed underdeveloped calcarine and parieto-occipital sulci. In addition, significant delayed maturation pattern was also observed in regions distant to ventricular system including Insula depth (controls 30.8 mm [SD 1.7] vs INSVM 31.7 mm [1.8]; P = .04), Sylvian fissure grading (>2 at 26 weeks: controls 87.5% vs INSVM 50%, P = .01), mesial area grading (>2 at 30 weeks: controls 95% vs INSVM 62.5%; P = .03), and cingulate sulcus grading (>2 at 30 weeks: controls 100% vs INSVM 80.5%; P = .01). CONCLUSIONS: Fetuses with INSVM showed underdeveloped cortical maturation including also regions, where effect of ventricular dilatation is unlikely. These results suggest that in a proportion of fetuses with INSVM, ventricular dilation might be related with altered cortical architecture.
Materia(s):	-Diagnòstic prenatal -Cervell -Ressonància magnètica -Neurobiologia del desenvolupament -Estudi de casos -Prenatal diagnosis -Brain -Magnetic resonance -Developmental neurobiology -Case studies
Derechos:	(c) John Wiley & Sons, 2018
Tipo de documento:	Artículo Artículo - Versión aceptada
Editor:	John Wiley & Sons
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