Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/125502
| dc.contributor.author | García Ayllón, María Salud |
|---|---|
| dc.contributor.author | Lopez Font, Inmaculada |
| dc.contributor.author | Boix, Claudia P. |
| dc.contributor.author | Fortea Ormaechea, Juan |
| dc.contributor.author | Sánchez del Valle Díaz, Raquel |
| dc.contributor.author | Lleó Bisa, Alberto |
| dc.contributor.author | Molinuevo, José Luis |
| dc.contributor.author | Zetterberg, Henrik |
| dc.contributor.author | Blennow, Kaj |
| dc.contributor.author | Sáez Valero, Javier |
| dc.date | 2018-10-22T15:45:55Z |
| dc.date | 2018-10-22T15:45:55Z |
| dc.date | 2017-05 |
| dc.date | 2018-10-22T15:45:56Z |
| dc.identifier | 2045-2322 |
| dc.identifier | 677413 |
| dc.identifier | 28559572 |
| dc.identifier.uri | http://hdl.handle.net/2445/125502 |
| dc.description | This study assesses whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal fluid (CSF) and their potential as biomarkers for Alzheimer's disease (AD). Immunoprecipitation and simultaneous assay by Western blotting using multiplex fluorescence imaging with specific antibodies against particular domains served to characterize CTFs of APP in human CSF. We demonstrate that APP-CTFs are detectable in human CSF, being the most abundant a 25-kDa fragment, probably resulting from proteolytic processing by η-secretase. The level of the 25-kDa APP-CTF was evaluated in three independent CSF sample sets of patients and controls. The CSF level of this 25-kDa CTF is higher in subjects with autosomal dominant AD linked to PSEN1 mutations, in demented Down syndrome individuals and in sporadic AD subjects compared to age-matched controls. Our data suggest that APP-CTF could be a potential diagnostic biomarker for AD. |
| dc.format | 7 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Nature Publishing Group |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-02841-7 |
| dc.relation | Scientific Reports, 2017, vol. 7, num. 1, p. 2477 |
| dc.relation | https://doi.org/10.1038/s41598-017-02841-7 |
| dc.rights | cc-by (c) García Ayllón, María Salud et al., 2017 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Malaltia d'Alzheimer |
| dc.subject | Marcadors bioquímics |
| dc.subject | Alzheimer's disease |
| dc.subject | Biochemical markers |
| dc.title | C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
Documentos relacionados
Otros documentos del mismo autor/a
García Ayllón, María Salud; Lopez Font, Inmaculada; Boix, Claudia P.; Fortea Ormaechea, Juan; Sánchez del Valle Díaz, Raquel; Lleó Bisa, Alberto; Molinuevo, José L.; Zetterberg, Henrik; Blennow, Kaj; Sáez Valero, Javier
Rubio Moscardo, Fanny; Setó Salvia, Núria; Pera, Marta; Bosch Morató, Mònica; Plata, Cristina; Belbin, Olivia; Gené, Gemma; Dols Icardo, Oriol; Ingelsson, Martin; Helisalmi, Seppo; Soininen, Hilkka; Hiltunen, Mikko; Giedraitis, Vilmantas; Lannfelt, Lars; Frank García, Ana; Bullido, María Jesús; Combarros, Onofre; Sánchez Juan, Pascual; Boada, Mercè; Tárraga, Lluís; Pastor, Pau; Pérez Tur, Jordi; Baquero, Miquel; Molinuevo, José Luis; Sánchez del Valle Díaz, Raquel; Fuentes Prior, Pablo; Fortea Ormaechea, Juan; Blesa González, Rafael; Muñoz, Francisco J.; Lleó Bisa, Alberto; Valverde, Miguel Ángel; Clarimón, Jordi
Tell Martí, Gemma; Puig Butillé, Joan Anton; Potrony Mateu, Míriam; Plana, Estel; Badenas Orquin, Celia; Antonell, Anna; Sánchez del Valle Díaz, Raquel; Molinuevo, José Luis; Lleó Bisa, Alberto; Alcolea, Daniel; Fortea Ormaechea, Juan; Fernandez-Santiago, Rubén; Clarimón, Jordi; Lladó Plarrumaní, Albert; Puig i Sardà, Susana
Tell-Marti, Gemma; Puig Butillé, Joan Anton; Potrony, Miriam; Plana, Estel; Badenas, Celia; Antonell, Anna; Sánchez del Valle Díaz, Raquel; Molinuevo, José L.; Lleó Bisa, Alberto; Alcolea, Daniel; Fortea Ormaechea, Juan; Fernandez-Santiago, Rubén; Clarimón, Jordi; Lladó Plarrumaní, Albert; Puig i Sardà, Susana
Rubio Moscardo, Fanny; Setó Salvia, Núria; Pera, Marta; Bosch Morató, Mònica; Plata, Cristina; Belbin, Olivia; Gené, Gemma; Dols Icardo, Oriol; Ingelsson, Martin; Helisalmi, Seppo; Soininen, Hilkka; Hiltunen, Mikko; Giedraitis, Vilmantas; Lannfelt, Lars; Frank, Ana; Bullido, M. Jesús; Combarros, Onofre; Sánchez Juan, Pascual; Boada, Mercè; Tárraga, Lluís; Pastor, Pau; Pérez Tur, Jordi; Baquero, Miquel; Molinuevo, José L.; Sánchez del Valle Díaz, Raquel; Fuentes Prior, Pablo; Fortea Ormaechea, Juan; Blesa, Rafael; Muñoz, Francisco J.; Lleó Bisa, Alberto; Valverde, Miguel A.; Clarimón, Jordi