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dc.contributor.author | Sepúlveda Martínez, Álvaro |
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dc.contributor.author | Rodríguez López, Mérida |
dc.contributor.author | Paz y Miño, Fernanda |
dc.contributor.author | Casu, Giulia |
dc.contributor.author | Crovetto, Francesca |
dc.contributor.author | Gratacós Solsona, Eduard |
dc.contributor.author | Crispi Brillas, Fàtima |
dc.date | 2018-10-24T15:46:28Z |
dc.date | 2019-09-11T05:10:18Z |
dc.date | 2018-09-11 |
dc.date | 2018-10-24T15:46:28Z |
dc.identifier | 0960-7692 |
dc.identifier | 682661 |
dc.identifier | 30207012 |
dc.identifier.uri | http://hdl.handle.net/2445/125607 |
dc.description | Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p<0.001) and higher prevalence of SGA (40.3% vs. 16.3%; p=0.001) and placental mediated disease (43.1% vs. 17.5%; p=0.001). After adjustment for confounder variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placental mediated disease in the following generation. This association was stronger in SGA mothers as compared to fathers. Conclusions: Our data provides evidence suggesting a transgenerational transmission of SGA highlighting the importance of public health strategies for preventing intrauterine growth impairment. |
dc.format | 28 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | John Wiley & Sons |
dc.relation | Versió postprint del document publicat a: https://doi.org/10.1002/uog.20119 |
dc.relation | Ultrasound in Obstetrics & Gynecology, 2018 |
dc.relation | https://doi.org/10.1002/uog.20119 |
dc.rights | (c) International Society of Ultrasound in Obstetrics & Gynecology (ISUOG), 2018 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Creixement fetal |
dc.subject | Medicina prenatal |
dc.subject | Fetal growth |
dc.subject | Prenatal medicine |
dc.title | Transgenerational transmission of small for gestational age |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/acceptedVersion |