A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Document Type

Article

Published version

Language

English

Subjects and keywords

Malaltia de Hodgkin; Cèl·lules B; Hodgkin's disease; B cells

Publisher

Nature Publishing Group

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Reproducció del document publicat a: https://doi.org/10.1038/ncomms6751

Nature Communications, 2015, vol. 6

https://doi.org/10.1038/ncomms6751

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cc by (c) Vijai et al., 2015

http://creativecommons.org/licenses/by/3.0/es/

This item appears in the following Collection(s)

Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL) [6906]

ISGlobal - Institut de Salut Global de Barcelona [61336]