dc.contributor.author
Slager, Susan L.
dc.contributor.author
Caporaso, Neil E.
dc.contributor.author
Sanjosé Llongueras, Silvia de
dc.contributor.author
Goldin, Lynn R.
dc.date.issued
2018-11-23T14:12:43Z
dc.date.issued
2018-11-23T14:12:43Z
dc.date.issued
2018-07-24T12:45:40Z
dc.identifier
https://hdl.handle.net/2445/126406
dc.description.abstract
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL. (C) 2013 Elsevier Inc. All rights reserved.
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1053/j.seminhematol.2013.09.007
dc.relation
Seminars in Hematology, 2013, vol. 50, num. 4, p. 296-302
dc.relation
https://doi.org/10.1053/j.seminhematol.2013.09.007
dc.rights
(c) Elsevier, 2013
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject
Leucèmia limfocítica crònica
dc.subject
Chronic lymphocytic leukemia
dc.title
Genetic Susceptibility to Chronic Lymphocytic Leukemia
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
