Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia

Home | About RECERCAT | Contact

Català | Castellano

All of RECERCAT

By Communities &
Collections By Defense Date By Authors By Titles By Subject

This Collection

By Defense Date By Authors By Titles By Subject

Statistics

View Statistics All RECERCAT

My RECERCAT

Other repositories directory

RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/136397

dc.contributor.author	Ceccato, Adrian
dc.contributor.author	Panagiotarakou, Meropi
dc.contributor.author	Ranzani, Otavio T.
dc.contributor.author	Martín Fernández, Marta
dc.contributor.author	Almansa Mora, Raquel
dc.contributor.author	Gabarrús, Albert
dc.contributor.author	Bueno, Leticia
dc.contributor.author	Cillóniz, Catia
dc.contributor.author	Liapikou, Adamantia
dc.contributor.author	Ferrer, Miquel
dc.contributor.author	Bermejo Martín, Jesús
dc.contributor.author	Torres Martí, Antoni
dc.date	2019-07-03T09:27:26Z
dc.date	2019-07-03T09:27:26Z
dc.date	2019-01-01
dc.date	2019-07-02T19:29:19Z
dc.identifier	2077-0383
dc.identifier	698272
dc.identifier	5639991
dc.identifier	31200458
dc.identifier.uri	http://hdl.handle.net/2445/136397
dc.description	Background: Intensive care unit-acquired pneumonia (ICU-AP) is a severe complication in patients admitted to the ICU. Lymphocytopenia is a marker of poor prognosis in patients with community-acquired pneumonia, but its impact on ICU-AP prognosis is unknown. We aimed to evaluate whether lymphocytopenia is an independent risk factor for mortality in non-immunocompromised patients with ICU-AP. Methods: Prospective observational cohort study of patients from six ICUs of an 800-bed tertiary teaching hospital (2005 to 2016). Results: Of the 473 patients included, 277 (59%) had ventilator-associated pneumonia (VAP). Receiver operating characteristic (ROC) analysis of the lymphocyte counts at diagnosis showed that 595 cells/mm3 was the best cut-off for discriminating two groups of patients at risk: lymphocytopenic group (lymphocyte count <595 cells/mm3 , 141 patients (30%)) and non-lymphocytopenic group (lymphocyte count ≥595 cells/mm3 , 332 patients (70%)). Patients with lymphocytopenia presented more comorbidities and a higher sequential organ failure assessment (SOFA) score at the moment of pneumonia diagnosis. Also, 28-day mortality and 90-day mortality were higher in patients with lymphocytopenia (28-day: 38 (27%) versus 59 (18%), 90-day: 74 (53%) versus 111 (34%)). In the multivariable model, <595 cells/mm3 resulted to be an independent predictor for 90-day mortality (Hazard Ratio 1.41; 95% Confidence Interval 1.02 to 1.94). Conclusion: Lymphocytopenia is an independent predictor of 90-day mortality in non-immunocompromised patients with ICU-AP.
dc.format	11 p.
dc.format	application/pdf
dc.language	eng
dc.relation	Reproducció del document publicat a: https://doi.org/10.3390/jcm8060843
dc.relation	Journal of Clinical Medicine, 2019, vol. 8, num. 6, 843
dc.relation	https://doi.org/10.3390/jcm8060843
dc.rights	cc by (c) Ceccato et al., 2019
dc.rights	http://creativecommons.org/licenses/by/3.0/es/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Pneumònia adquirida a la comunitat
dc.subject	Mortalitat
dc.subject	Community-acquired pneumonia
dc.subject	Mortality
dc.title	Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

Show simple item record

All of RECERCAT

This Collection

Statistics

My RECERCAT

Related documents

Other documents of the same author