dc.contributor.author
Gamir Morralla, Andrea
dc.contributor.author
Belbin, Olivia
dc.contributor.author
Fortea Ormaechea, Juan
dc.contributor.author
Alcolea, Daniel
dc.contributor.author
Ferrer, Isidro (Ferrer Abizanda)
dc.contributor.author
Lleó Bisa, Alberto
dc.contributor.author
Iglesias, Teresa
dc.date.issued
2019-07-15T10:46:49Z
dc.date.issued
2019-07-15T10:46:49Z
dc.date.issued
2019-07-15T10:46:50Z
dc.identifier
https://hdl.handle.net/2445/137239
dc.description.abstract
Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrospinal fluid (CSF) of controls and AD patients. Only the N-terminal antibody showed a positive correlation between Kidins220 and phosphorylated tau in AD brains. Using this antibody, Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. This study highlights the potential of Kidins220 as a CSF biomarker in AD.
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.3233/JAD-160639
dc.relation
Journal of Alzheimer's Disease, 2017, vol. 55, num. 4, p. 1327-1333
dc.relation
https://doi.org/10.3233/JAD-160639
dc.rights
(c) Gamir Morralla, Andrea et al., 2017
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject
Malaltia d'Alzheimer
dc.subject
Líquid cefalorraquidi
dc.subject
Proteïnes de membrana
dc.subject
Alzheimer's disease
dc.subject
Cerebrospinal fluid
dc.subject
Membrane proteins
dc.title
Kidins220 correlates with tau in Alzheimer's disease brain and cerebrospinal fluid
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
