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Title:	Cortical gray matter and hippocampal atrophy in idiopathic Rapid Eye Movement sleep behavior disorder
Author:	Campabadal, Anna; Segura i Fàbregas, Bàrbara; Junqué i Plaja, Carme, 1955-; Serradell, Mónica; Abós, Alexandra; Uribe Codesal, Carme; Baggio, Hugo César; Gaig Ventura, Carles; Santamaria Cano, Joan; Compta, Yaroslau; Bargalló Alabart, Núria​; Iranzo, Alex
Notes:	Objective: In this study we investigate cortical and subcortical gray matter structure in patients with Idiopathic REM-sleep behavior disorder (IRBD), and their relation to cognitive performance. Methods: This study includes a sample of 20 patients with polysomnography-confirmed IRBD and 27 healthy controls that underwent neuropsychological and T1-weighted MRI assessment. FreeSurfer was used to estimate cortical thickness, subcortical volumetry (version 5.1), and hippocampal subfields segmentation (version 6.0). FIRST, FSL's model-based segmentation/registration tool was used for hippocampal shape analysis. Results: Compared with healthy subjects, IRBD patients showed impairment in facial recognition, verbal memory, processing speed, attention, and verbal naming. IRBD patients had cortical thinning in left superior parietal, post-central, and fusiform regions, as well as in right superior frontal and lateral occipital regions. Volumetric and shape analyses found right hippocampal atrophy in IRBD, specifically in posterior regions. Hippocampal subfields exploratory analysis identified significant differences in the right CA1, molecular layer, granule cell layer of dentate gyrus, and CA4 of this patients. No correlations were found between cognitive performance and brain atrophy. Conclusion: This work confirms the presence of posterior based cognitive dysfunction, as well as cortical and right hippocampal atrophy in IRBD patients.
Subject(s):	-Trastorns del son -Imatges per ressonància magnètica -Trastorns de la cognició -Sleep disorders -Magnetic resonance imaging -Cognition disorders
Rights:	cc-by (c) Campabadal, Anna et al., 2019 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Frontiers Media
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