Integrated mechanisms of anticipation and rate-of-change computations in cortical circuits

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/148048

dc.contributor.author	Puccini, Gabriel D.
dc.contributor.author	Sánchez-Vives, María Victoria
dc.contributor.author	Compte Braquets, Albert
dc.date	2020-01-16T15:25:26Z
dc.date	2020-01-16T15:25:26Z
dc.date	2007-03-26
dc.date	2020-01-16T15:25:26Z
dc.identifier	1553-734X
dc.identifier	http://hdl.handle.net/2445/148048
dc.identifier	618589
dc.identifier.uri	http://hdl.handle.net/2445/148048
dc.description	Local neocortical circuits are characterized by stereotypical physiological and structural features that subserve generic computational operations. These basic computations of the cortical microcircuit emerge through the interplay of neuronal connectivity, cellular intrinsic properties, and synaptic plasticity dynamics. How these interacting mechanisms generate specific computational operations in the cortical circuit remains largely unknown. Here, we identify the neurophysiological basis of both the rate of change and anticipation computations on synaptic inputs in a cortical circuit. Through biophysically realistic computer simulations and neuronal recordings, we show that the rate-of-change computation is operated robustly in cortical networks through the combination of two ubiquitous brain mechanisms: short-term synaptic depression and spike-frequency adaptation. We then show how this rate-of-change circuit can be embedded in a convergently connected network to anticipate temporally incoming synaptic inputs, in quantitative agreement with experimental findings on anticipatory responses to moving stimuli in the primary visual cortex. Given the robustness of the mechanism and the widespread nature of the physiological machinery involved, we suggest that rate-of-change computation and temporal anticipation are principal, hard-wired functions of neural information processing in the cortical microcircuit.
dc.format	13 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation	Reproducció del document publicat a: https://doi.org/10.1371/journal.pcbi.0030082
dc.relation	PLoS Computational Biology, 2007, vol. 3, num. 5, p. e82
dc.relation	https://doi.org/10.1371/journal.pcbi.0030082
dc.rights	cc-by (c) Puccini, Gabriel D. et al., 2007
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Escorça cerebral
dc.subject	Neuroplasticitat
dc.subject	Fisiologia cel·lular
dc.subject	Cerebral cortex
dc.subject	Neuroplasticity
dc.subject	Cell physiology
dc.title	Integrated mechanisms of anticipation and rate-of-change computations in cortical circuits
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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