Annexins in adipose tissue: Novel players in obesity

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Grewal, Thomas
dc.contributor.author	Enrich Bastús, Carles
dc.contributor.author	Rentero Alfonso, Carles
dc.contributor.author	Buechler, Christa
dc.date	2020-01-24T18:52:50Z
dc.date	2020-01-24T18:52:50Z
dc.date	2019-07-13
dc.date	2020-01-24T18:52:51Z
dc.identifier	1661-6596
dc.identifier	http://hdl.handle.net/2445/148699
dc.identifier	694858
dc.identifier.uri	http://hdl.handle.net/2445/148699
dc.description	Obesity and the associated comorbidities are a growing health threat worldwide. Adipose tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic diseases related to obesity. In particular, the excess storage of lipids in adipose tissues disturbs cellular homeostasis. Amongst others, organelle function and cell signaling, often related to the altered composition of specialized membrane microdomains (lipid rafts), are affected. Within this context, the conserved family of annexins are well known to associate with membranes in a calcium (Ca2+)- and phospholipid-dependent manner in order to regulate membrane-related events, such as trafficking in endo- and exocytosis and membrane microdomain organization. These multiple activities of annexins are facilitated through their diverse interactions with a plethora of lipids and proteins, often in different cellular locations and with consequences for the activity of receptors, transporters, metabolic enzymes, and signaling complexes. While increasing evidence points at the function of annexins in lipid homeostasis and cell metabolism in various cells and organs, their role in adipose tissue, obesity and related metabolic diseases is still not well understood. Annexin A1 (AnxA1) is a potent pro-resolving mediator affecting the regulation of body weight and metabolic health. Relevant for glucose metabolism and fatty acid uptake in adipose tissue, several studies suggest AnxA2 to contribute to coordinate glucose transporter type 4 (GLUT4) translocation and to associate with the fatty acid transporter CD36. On the other hand, AnxA6 has been linked to the control of adipocyte lipolysis and adiponectin release. In addition, several other annexins are expressed in fat tissues, yet their roles in adipocytes are less well examined. The current review article summarizes studies on the expression of annexins in adipocytes and in obesity. Research efforts investigating the potential role of annexins in fat tissue relevant to health and metabolic disease are discussed.
dc.format	23 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	MDPI
dc.relation	Reproducció del document publicat a: https://doi.org/10.3390/ijms20143449
dc.relation	International Journal of Molecular Sciences, 2019, vol. 20, num. 14
dc.relation	https://doi.org/10.3390/ijms20143449
dc.rights	cc-by (c) Grewal, Thomas et al., 2019
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Colesterol
dc.subject	Obesitat
dc.subject	Teixit adipós
dc.subject	Cholesterol
dc.subject	Obesity
dc.subject	Adipose tissues
dc.title	Annexins in adipose tissue: Novel players in obesity
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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