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Título:	Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
Autor/a:	García-Otero, Laura; López, Marta; Guitart Mampel, Mariona; Morén Núñez, Constanza; Goncé Mellgren, Anna; Esteve, Carol; Salazar, Laura; Gómez, Olga; Martínez Crespo, Josep M. (Josep Maria); Torres, Berta; César, Sergi; Garrabou Tornos, Glòria; Crispi Brillas, Fàtima; Gratacós Solsona, Eduard
Notas:	Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat] BACKGROUND: Mitochondrial toxicity related to maternal combined antiretroviral treatment (cART) may have an impact on the heart of HIV-exposed uninfected (HEU) fetuses. Our objective was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies. METHODS: Prospective cohort including 47 HIV-infected and 47 non HIV-infected pregnancies. Fetal echocardiography was performed at 26-32 weeks of pregnancy. Umbilical cord blood and placental tissue were collected to study mitochondrial DNA content (mtDNA) (ratio 12SrRNA/RNAseP) and mitochondrial function (cytochrome c oxidase, COX, enzymatic activity) normalized by mitochondrial content (citrate synthase, CS). RESULTS: HEU fetuses showed hypertrophic hearts (left myocardial wall thickness: HIV mean 3.21 mm (SD 0.81) vs. non-HIV 2.72 (0.42), p = 0.012), with signs of systolic and diastolic dysfunction (isovolumic relaxation time: HIV 52.2 ms (8.85) vs. non-HIV 42.5 ms (7.30); p<0.001). Cord blood mitochondrial content was significantly increased in HIV-exposed fetuses (CS activity: HIV 82.9 nmol/min.mg of protein (SD 40.5) vs. non-HIV 56.7 nmol/min.mg of protein (28.4); p = 0.007), with no differences in mtDNA content and COX activity. Both myocardial and mitochondrial mass parameters were significantly associated with zidovudine exposure. CONCLUSIONS: HEU fetuses showed signs of increased myocardial and mitochondrial mass associated with maternal zidovudine treatment, suggesting a fetal adaptive response to cART toxicity.
Materia(s):	-Fetus -Antiretrovirals -VIH (Virus) -Fetus -Antiretroviral agents -HIV (Viruses)
Derechos:	cc-by (c) García-Otero, Laura et al., 2019 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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