Mixed Features in Depression: The Unmet Needs of Diagnostic and Statistical Manual of Mental Disorders Fifth Edition

Author

Pacchiarotti, Isabella

Kotzalidis, Georgios D.

Murru, Andrea

Mazzarini, Lorenzo

Rapinesi, Chiara

Valentí Ribas, Marc

Anmella, Gerard

Gomes da Costa, Susana

Giménez Palomo, Anna

Llach, Cristian

Perugi, Giulio

Vieta i Pascual, Eduard, 1963-

Verdolini, Norma

Publication date

2020-02-21T12:29:50Z

2021-03-31T05:10:18Z

2020-03

2020-02-21T12:29:51Z

Abstract

The identification of mixed features during a major depressive episode is important due to the worse course and treatment issues associated with this condition. Diagnostic and Statistical Manual of Mental Disorders Fifth Edition mixed features specifier criteria are controversial, because it includes typical manic symptoms, whereas it excludes overlapping excitatory symptoms that are frequently reported in mixed depression. Psychomotor agitation, mood lability, and aggressiveness are the new proposed criteria based on the results of the Bipolar Disorders: Improving Diagnosis, Guidance and Education-II-Mix study. Several clinical and course indicators of bipolarity were found to be associated with the presence of mixed characteristics, mainly overlapping excitatory symptoms, during a major depressive episode.

Document Type

Article
Accepted version

Language

English

Subjects and keywords

Trastorn bipolar; Depressió psíquica; Símptomes; Manic-depressive illness; Mental depression; Symptoms

Publisher

Elsevier

Related items

Versió postprint del document publicat a: https://doi.org/10.1016/j.psc.2019.10.006

Psychiatric Clinics of North America, 2020, vol. 43, num. 1, p. 59-68

https://doi.org/10.1016/j.psc.2019.10.006

Rights

cc-by-nc-nd (c) Elsevier, 2020

http://creativecommons.org/licenses/by-nc-nd/3.0/es