A practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines

Publication date

2020-06-03T09:40:22Z

2020-06-03T09:40:22Z

2012-01-06

2020-06-03T09:40:22Z

Abstract

Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of an unsaturated δ-keto ester derivative with (R)-phenylglycinol and the stereoselective hydrogenation of the resulting tricyclic oxazoloquinolone lactams.

Document Type

Article


Accepted version

Language

English

Publisher

American Chemical Society

Related items

Versió postprint del document publicat a: https://doi.org/10.1021/ol2030058

Organic Letters, 2012, vol. 14, num. 1, p. 210-213

https://doi.org/10.1021/ol2030058

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(c) American Chemical Society , 2012