dc.contributor.author
Esteller, Manel
dc.date.issued
2021-04-15T10:35:56Z
dc.date.issued
2021-04-15T10:35:56Z
dc.date.issued
2008-03-13
dc.date.issued
2021-04-15T10:35:57Z
dc.identifier
https://hdl.handle.net/2445/176325
dc.description.abstract
Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name "the causal interactions between genes and their products, which bring the phenotype into being," epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence.
dc.format
application/pdf
dc.publisher
Massachusetts Medical Society
dc.relation
Reproducció del document publicat a: https://doi.org/10.1056/NEJMra072067
dc.relation
New England Journal of Medicine, 2008, vol. 358, num. 11, p. 1148-1159
dc.relation
https://doi.org/10.1056/NEJMra072067
dc.rights
(c) Massachusetts Medical Society, 2008
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Ciències Fisiològiques)
dc.subject
Expressió gènica
dc.subject
Proteïnes supressores de tumors
dc.subject
Gene expression
dc.subject
Tumor suppressor protein
dc.title
Epigenetics in Cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
