Universitat de Barcelona
2021-08-31T10:31:28Z
2021-08-31T10:31:28Z
2011-05-09
2021-08-31T10:31:28Z
An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.
Article
Accepted version
English
RNA; Nucleòsids; Estructura molecular; RNA; Nucleosides; Molecular structure
American Chemical Society
Versió postprint del document publicat a: https://doi.org/10.1021/ol200909j
Organic Letters, 2011, vol. 13, num. 11, p. 2888-2891
https://doi.org/10.1021/ol200909j
(c) American Chemical Society , 2011
