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Modified siRNAs for the study of the PAZ domain

Author

Somoza, Álvaro

Terrazas Martínez, Montserrat

Eritja i Casadellà, Ramon

Publication date

2021-08-31T11:41:03Z

2021-08-31T11:41:03Z

2010-05-19

2021-08-31T11:41:03Z

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Abstract

Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

Document Type

Article

Accepted version

Language

English

Subjects and keywords

RNA; Fixació de proteïnes; Modificació química de les proteïnes; RNA; Protein binding; Chemical modification of proteins

Publisher

Royal Society of Chemistry

Related items

Versió postprint del document publicat a: https://doi.org/10.1039/C003221B

Chemical Communications, 2010, vol. 46, p. 4270-4272

https://doi.org/10.1039/C003221B

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Rights

(c) Somoza, Álvaro et al., 2010

This item appears in the following Collection(s)

Institut de Recerca Biomèdica (IRB Barcelona) [418]

ISGlobal - Institut de Salut Global de Barcelona [61308]

Química Inorgànica i Orgànica [1012]