dc.contributor.author
Nicolàs-Aragó, Adrià
dc.contributor.author
Fort i Baixeras, Joana
dc.contributor.author
Palacín Prieto, Manuel
dc.contributor.author
Errasti-Murugarren, Ekaitz
dc.date.issued
2022-04-01T13:53:51Z
dc.date.issued
2022-04-01T13:53:51Z
dc.date.issued
2021-08-01
dc.date.issued
2022-04-01T13:53:51Z
dc.identifier
https://hdl.handle.net/2445/184597
dc.description.abstract
The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare diseases and acquired diseases, such as cancer. In the last four years, several crystal or cryo-EM structures of LATs and CATs have been solved. These structures have started to fill our knowledge gap that previously was based on the structural biology of remote homologs of the amino acid-polyamine-organocation (APC) transporters. This review recovers this structural and functional information to start generating the molecular bases of the transport cycle of LATs. Special attention is given to the known transporter conformations within the transport cycle and the molecular bases for substrate interaction and translocation, including the asymmetric interaction of substrates at both sides of the plasma membrane. Keywords: APC; LATs; SLC7; transport cycle; structure; substrate binding; substrate translocation
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/membranes11080602
dc.relation
Membranes, 2021, vol. 11, num. 8, p. 1-13
dc.relation
https://doi.org/10.3390/membranes11080602
dc.rights
cc-by (c) Nicolàs-Aragó, Adrià et al., 2021
dc.rights
https://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject
Proteïnes portadores
dc.subject
Malalties rares
dc.subject
Carrier proteins
dc.title
Rush hour of LATs towards their transport cycle
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
