dc.contributor.author
Kurdián, Melania
dc.contributor.author
Herrero Fresneda, Immaculada
dc.contributor.author
Lloberas Blanch, Núria
dc.contributor.author
Giménez Bonafé, Pepita
dc.contributor.author
Coria, Virginia
dc.contributor.author
Grande, María T.
dc.contributor.author
Boggia, José
dc.contributor.author
Malacrida, Leonel
dc.contributor.author
Torras Ambròs, Joan
dc.contributor.author
Arévalo, Miguel A.
dc.contributor.author
González-Martínez, Francisco
dc.contributor.author
López-Novoa, José M.
dc.contributor.author
Grinyó Boira, Josep M.
dc.contributor.author
Noboa, Oscar
dc.date.issued
2013-04-11T11:31:24Z
dc.date.issued
2013-04-11T11:31:24Z
dc.date.issued
2012-03-12
dc.date.issued
2013-04-11T11:31:24Z
dc.identifier
https://hdl.handle.net/2445/34526
dc.description.abstract
The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.
dc.format
application/pdf
dc.publisher
Public Library of Science (PLoS)
dc.relation
Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032516
dc.relation
PLoS One, 2012, vol. 7, núm. 3, p. e32516
dc.relation
http://dx.doi.org/10.1371/journal.pone.0032516
dc.rights
cc-by (c) Kurdián et al., 2012
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Ciències Fisiològiques)
dc.subject
Transplantament renal
dc.subject
Immunosupressió
dc.subject
Kidney transplantation
dc.subject
Immunosuppression
dc.title
Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
