dc.contributor.author
Aiguabella Font, Núria
dc.contributor.author
Pesquer, Albert
dc.contributor.author
Verdaguer i Espaulella, Xavier
dc.contributor.author
Riera i Escalé, Antoni
dc.date.issued
2014-02-20T13:16:35Z
dc.date.issued
2014-05-28T22:02:23Z
dc.date.issued
2013-05-28
dc.date.issued
2014-02-20T12:18:26Z
dc.identifier
https://hdl.handle.net/2445/50467
dc.description.abstract
A new approach to the synthesis of 4,5-disubstituted cyclopentenones is described. The strategy is based on the Pauson-Khand (PK) reaction of norbornadiene and N-Boc-propargylamine as alkyne with a masked leaving group, which can be eliminated at will. This approach to the synthesis of 4,5-disubstituted cyclopentenones overcomes the problem of using the alkylation to introduce the alpha-side-chain. As an example, prostane 13-epi-12-oxo-phytodienoic acid (13-epi-12-oxo-PDA) methyl ester was synthesized.
dc.format
application/pdf
dc.publisher
American Chemical Society
dc.relation
Versió postprint del document publicat a: http://dx.doi.org/10.1021/ol400999a
dc.relation
Organic Letters, 2013, vol. 15, num. 11, p. 2696-2699
dc.relation
http://dx.doi.org/10.1021/ol400999a
dc.rights
(c) American Chemical Society , 2013
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject
Ciclització (Química)
dc.subject
Química biorgànica
dc.subject
Compostos orgànics
dc.subject
Síntesi orgànica
dc.subject
Efecte de l'estrès sobre les plantes
dc.subject
Estrès (Psicologia)
dc.subject
Prostaglandines
dc.subject
Ring formation (Chemistry)
dc.subject
Bioorganic chemistry
dc.subject
Organic compounds
dc.subject
Organic synthesis
dc.subject
Effect of stress on plants
dc.subject
Stress (Psychology)
dc.subject
Prostaglandins
dc.title
Pauson-Khand Adducts of N-Boc-propargylamine: A New Approach to 4,5-Disubstituted Cyclopentenones
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
