CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer

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Title:	CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer
Author:	Stefansson, Olafur A.; Esteller, Manel
Abstract:	In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer.
Subject(s):	-Càncer -Metàstasi -Cromatina -Cancer -Metastasis -Chromatin
Rights:	cc-by (c) Stefansson, Olafur A. et al., 2014 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	BioMed Central
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