Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/116933

Título:	BDNF and NGF signalling in early phases of psychosis: relationship with inflammation and response to antipsychotics after a 1 year
Autor/a:	Martínez Cengotitabengoa, Mónica; MacDowell, Karina S.; Alberich, Susana; Díaz, FJ.; García-Bueno, Borja; Rodriguez Jimenez, Roberto; Bioque Alcázar, Miquel; Berrocoso, Esther; Parellada, Mara; Lobo, Antonio; Saiz, Pilar A.; Matute, Carlos; Bernardo Arroyo, Miquel; González-Pinto, Ana; Leza, Juan Carlos
Notas:	Previous studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs
Materia(s):	-Psicosi -Trastorns afectius -Antipsicòtics -Farmacologia -Estudi de casos -Inflamació -Psychoses -Affective disorders -Antipsychotic drugs -Pharmacology -Case studies -Inflammation
Derechos:	cc-by-nc-nd (c) Martínez-Cengotitabengoa, Mónica et al., 2015 http://creativecommons.org/licenses/by-nc-nd/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Oxford University Press
Compartir:

Mostrar el registro completo del ítem