Comparison of three central venous catheterization techniques in term and preterm neonates: a randomised, parallel-group, multicentre, non-inferiority, and open-labelled clinical trial

Abstract

Background: Central venous catheterizations in term and preterm neonates can be challenging, even in experienced hands. The use of US guidance for its placement increases the success rate and decreases complications. There are different techniques, the most used nowadays is through the internal jugular vein access; however, this approach is difficult in this population, and there are others, such as the supraclavicular and brachiocephalic vein’, that must be considered in clinical practice. Objective: To compare the efficacy between BCV, SCV and IJV catheterizations in term and preterm neonates. Design: This study will be a randomised, parallel-group, multicentre, non-inferiority, and open-labelled clinical trial. Participants: Every preterm or term neonate admitted in NICU that requires a central venous catheter. We will enrol 114 patients during 1 year from 3 Spanish hospitals. These patients will be randomised into three groups, one for each technique of catheterization