Sistema de Salut de Catalunya
Bonfill, Marina
Vilaplana Blanes, Andrea
Conde, Carmen
Aguilera, Carlota
Diaz de Heredia, Cristina
Institut Català de la Salut
[Bonfill M, Vilaplana A, Aguilera C] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Conde C] Servei d’Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Diaz de Heredia C] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-11-10T07:18:24Z
2025-11-10T07:18:24Z
2025-08-29
Health-related quality of life; Caregiver; Allogeneic hematopoietic stem cell transplantation
Qualitat de vida relacionada amb la salut; Cuidadors; Trasplantament al·logènic de cèl·lules mare hematopoètiques
Calidad de vida relacionada con la salud; Cuidadores; Trasplante alogénico de células madre hematopoyéticas
Purpose The purpose of this study was to analyze the patients’ and caregivers’ perceptions of health-related quality of life (HRQOL) of pediatric allogeneic hematopoietic stem cell transplant (HSCT) recipients. The perceptions in HRQOL of patients and their caregivers were studied using PROMS (patient-reported outcome measures) questionnaires. Methods Retrospective analysis of data from children and adolescents who underwent HSCT at our hospital between 2017 and 2022. The self-report and parent-proxy report versions of the Pediatric Quality of Life Inventory 4.0 generic core scales (PedsQL 4.0) were used to assess HRQOL in four areas (physical, emotional, social, and school functioning) as reported by patients aged ≥ 2 to < 18 years and their caregivers and evaluated 1 and 2 years after hospital discharge allogeneic HSCT. Results We collected data on the HRQOL of 36 patients and their caregivers through self- and proxy-reports. More than 70% of children and their caregivers perceived good HRQOL in all areas both 1 and 2 years after allogeneic HSCT. Patients and caregivers largely agreed in their assessments, although caregivers gave slightly higher HRQOL ratings. Children aged < 10 years had higher HRQOL scores than adolescents at both time points. Patients with an HLA-mismatched donor were at greater risk of impaired HRQOL than those with an HLA-matched donor, particularly in terms of physical functioning. Conclusions More than 70% of patients and caregivers perceived good overall HRQOL (total PedsQL score) 2 years after hospital discharge from the HSCT unit.
Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.
Anglès
Pacients - Satisfacció; Cèl·lules mare hematopoètiques - Trasplantació; Infants; HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Transplantation::Transplantation, Homologous; NAMED GROUPS::Persons::Age Groups::Child; ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::trasplante::trasplante homólogo; DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño
Springer Nature
SN Comprehensive Clinical Medicine;7
https://doi.org/10.1007/s42399-025-02040-w
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3375]
Articles científics - VHIR [1654]
