dc.contributor
Institut Català de la Salut
dc.contributor
[Bonfill M, Vilaplana A, Aguilera C] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Conde C] Servei d’Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Diaz de Heredia C] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Bonfill, Marina
dc.contributor.author
Vilaplana Blanes, Andrea
dc.contributor.author
Conde, Carmen
dc.contributor.author
Aguilera, Carlota
dc.contributor.author
Diaz de Heredia, Cristina
dc.date.accessioned
2025-11-13T16:54:14Z
dc.date.available
2025-11-13T16:54:14Z
dc.date.issued
2025-11-10T07:18:24Z
dc.date.issued
2025-11-10T07:18:24Z
dc.date.issued
2025-08-29
dc.identifier
Bonfill M, Vilaplana A, Conde C, Aguilera C, Diaz-de-Heredia C. Patient and Caregiver Perceptions of Health-Related Quality of Life in Children and Adolescents After Allogeneic Hematopoietic Stem Cell Transplantation. SN Compr Clin Med. 2025 Aug 29;7:281.
dc.identifier
http://hdl.handle.net/11351/14046
dc.identifier
10.1007/s42399-025-02040-w
dc.identifier.uri
http://hdl.handle.net/11351/14046
dc.description.abstract
Health-related quality of life; Caregiver; Allogeneic hematopoietic stem cell transplantation
dc.description.abstract
Qualitat de vida relacionada amb la salut; Cuidadors; Trasplantament al·logènic de cèl·lules mare hematopoètiques
dc.description.abstract
Calidad de vida relacionada con la salud; Cuidadores; Trasplante alogénico de células madre hematopoyéticas
dc.description.abstract
Purpose
The purpose of this study was to analyze the patients’ and caregivers’ perceptions of health-related quality of life (HRQOL) of pediatric allogeneic hematopoietic stem cell transplant (HSCT) recipients. The perceptions in HRQOL of patients and their caregivers were studied using PROMS (patient-reported outcome measures) questionnaires.
Methods
Retrospective analysis of data from children and adolescents who underwent HSCT at our hospital between 2017 and 2022. The self-report and parent-proxy report versions of the Pediatric Quality of Life Inventory 4.0 generic core scales (PedsQL 4.0) were used to assess HRQOL in four areas (physical, emotional, social, and school functioning) as reported by patients aged ≥ 2 to < 18 years and their caregivers and evaluated 1 and 2 years after hospital discharge allogeneic HSCT.
Results
We collected data on the HRQOL of 36 patients and their caregivers through self- and proxy-reports. More than 70% of children and their caregivers perceived good HRQOL in all areas both 1 and 2 years after allogeneic HSCT. Patients and caregivers largely agreed in their assessments, although caregivers gave slightly higher HRQOL ratings. Children aged < 10 years had higher HRQOL scores than adolescents at both time points. Patients with an HLA-mismatched donor were at greater risk of impaired HRQOL than those with an HLA-matched donor, particularly in terms of physical functioning.
Conclusions
More than 70% of patients and caregivers perceived good overall HRQOL (total PedsQL score) 2 years after hospital discharge from the HSCT unit.
dc.description.abstract
Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.
dc.format
application/pdf
dc.publisher
Springer Nature
dc.relation
SN Comprehensive Clinical Medicine;7
dc.relation
https://doi.org/10.1007/s42399-025-02040-w
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Pacients - Satisfacció
dc.subject
Cèl·lules mare hematopoètiques - Trasplantació
dc.subject
HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Transplantation::Transplantation, Homologous
dc.subject
NAMED GROUPS::Persons::Age Groups::Child
dc.subject
ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::trasplante::trasplante homólogo
dc.subject
DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño
dc.title
Patient and Caregiver Perceptions of Health-Related Quality of Life in Children and Adolescents After Allogeneic Hematopoietic Stem Cell Transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
