Universitat de Barcelona: Envíos recientes
Mostrando ítems 1-20 de 61256
Potent and Subtype-Selective Dopamine D-2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach
Using a previously unexplored, efficient, and versatile multicomponent method, we herein report the rapid generation of novel potent and subtype-selective DRD2 biased partial agonists. This strategy exemplifies the search ...
Paleoenvironmental constraints influencing charophyte communities in an Early Cretaceous Karstic Lake, La Pedrera de Meià Konservat-Lagerstätte (Southern Pyrenees): combining geochemical and palaeoecological analyses.
The combined sedimentological and palaeoecological analysis of charophyte-rich carbonate microfacies is proven to be a useful methodology for the palaeoenvironmental reconstruction of continental settings. However, the ...
Hydrophilic Janus Micelles from an ABC Triblock Copolymer
We describe the creation of an amphiphilic triblock copolymer that drives lateral phase separation within micelle coronas. The design combines a hydrophobic poly(lactide) (PLA) core ‑forming block with two distinct hydrophilic ...
Transferrin receptor 1-targeted polymersomes therapy for colorectal cancer
Colorectal cancer (CRC) ranks among the most common cancers and is the second leading cause of cancer-related</p><p>deaths. The high mortality associated with CRC is attributed mainly to difficulties in early detection and ...
Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
To evaluate the impact of applying the FIGO 2023 staging system compared with FIGO 2009 in a real-world cohort of patients with early-stage endometrial cancer who underwent surgery. This multicenter retrospective cohort ...
Report of three azole-resistant Aspergillus fumigatus cases with TR34/L98H mutation in hematological patients in Barcelona; Spain.
Objectives We aimed to report the emergence of azole-resistant invasive aspergillosis in hematologic patients admitted to a tertiary hospital in Spain during the last 4 months. Methods Prospective, descriptive study was ...
Females and Exercise Capacity Impairment in Heart Failure: A Sex-Focused Analysis
Heart failure (HF) is becoming increasingly common, especially in older females, and displays marked sex-related differences in pathophysiology, treatment, and outcomes. Submaximal exercise capacity (SEC), frequently ...
Regulation of the orphan G-protein–coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy
Megalencephalic leukoencephalopathy with subcortical cyst (MLC) is a rare leukodystrophy primarily caused by mutations in two genes: MLC1, encoding a membrane protein of unknown function, and GlialCAM, a cell adhesion ...
Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
Understanding how molecular features dictate the self-assembly of amphiphilic block copolymers into well-defined nanostructures is essential for the rational design of advanced soft materials. However, the large number of ...
No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M<sup>II</sup>(phosphane-κ<sup>2</sup><em>P</em>)}<sup>2+</sup> (M = Pd, Pt) Scaffolds
A series of square-planar palladium and platinum compounds with cis-blocking phosphanes and terminal azobenzene ligands ${[M(dppp)-(azo)_{2}] (OTf)_{2} (azo = CN(C_{6}H_{4})-N = N-(C_{6}H_{4})CN (iso-cyano), CN(C_{6}H_{4})-N ...
Follow the median: revisiting bubbles and cycles
Under very general conditions, the best predictor of any random variable’s observed time series is not its mean but its median. Hence, if we aim to model a variable with a skewed (a.k.a. asymmetric) probability distribution, ...
The Network Structure of the Urban Revolution
Although long-distance interaction dates back to Prehistory, the scale and complexity of exchange during the Urban Revolution are unparalleled. How did early urban societies organize transcontinental trade without modern ...
On the relevance of query definition in the performance of 3D ligand-based virtual screening
Ligand-based virtual screening (LBVS) methods are widely used to explore the vast chemical space in the search of novel compounds resorting to a variety of properties encoded in 1D, 2D or 3D descriptors. The success of ...
Clinical Characteristics and Surgical Outcomes of Patients Receiving Perioperative Pembrolizumab in KEYNOTE-671
BACKGROUND The phase 3 KEYNOTE-671 study (NCT03425643) demonstrated significantly improved event-free survival (EFS) and overall survival with neoadjuvant pembrolizumab plus chemotherapy followed by surgery and adjuvant ...
Democratic backsliding in times of crisis
In a political-agency model, an incumbent can initiate a restrictive policy in response to a crisis state of the world. Both the opposition and the citizen value the incumbent's policy matching the state; however, they ...
La Biblioteca del Pavelló de la República, un referent per a l’estudi del moviment obrer
El fons de la Biblioteca del Pavelló de la República de la Universitat de Barcelona és un referent obligatori per a l’estudi del moviment obrer dels segles XIX i XX a Catalunya, a l’Estat espanyol i a diversos països tant ...
Global analysis of µ→e interactions in the SMEFT
We study current experimental bounds on charged lepton flavor violating (CLFV) μ – e interactions in the model-independent framework of the Standard Model Effective Field Theory (SMEFT). Assuming a generic flavor structure ...
Assessment of the a2(1320) tensor-meson contribution to η/η′→π0γγ decays
In light of the recent measurement of the η→π0γγ decay by the KLOE-2 Collaboration, a previous analysis including vector- and scalar-meson exchange contributions using the vector meson dominance and linear sigma model ...
A cinenurducation activity using Call the Midwife to teach about sexually transmitted infections and preeclampsia: design, implementation, and assessment
Background: Nursing students need to learn about sexually transmitted infections and preeclampsia. Cinenureducation is a rigorous method that uses materials from commercial movies or television series to teach health ...
Lectura colaborativa y multimodal: innovación pedagógica en la lectura de Romeo y Julieta en estudiantes chilenos de secundaria
Reading assessments in educational institutions in Chile usually consist of closed-ended questions with multiple choice. This practice is commonly known as home reading, since students have a month to read the book at home. ...
