Ni-catalyzed Divergent Cyclization/Carboxylation of Unactivated Primary and Secondary Alkyl Halides with CO2

Abstract

<p> &nbsp;</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> A user-friendly Ni-catalyzed reductive</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> cyclization/carboxylation of <i>unactivated </i>alkyl halides</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> with CO<span style="font: 7.0px 'Times New Roman'">2 </span>is described. The protocol operates under mild</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> conditions with excellent chemoselectivity profile and a</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> divergent <i>syn/anti-</i>selectivity pattern that can be easily</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> modulated by the substrate utilized.</p>