Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2

Abstract

<p> A catalytic carboxylation of unactivated primary, secondary &amp; tertiary alkyl chlorides with CO₂ at atmospheric pressure is described. This protocol represents the first <em>intermolecular </em>cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowledge in the cross-coupling arena.</p>