Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm

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To access the full text documents, please follow this link: http://hdl.handle.net/10230/35238

dc.contributor.author	Mochol, Gabriela
dc.contributor.author	Kiryk, Anna
dc.contributor.author	Mochol, Gabriela
dc.contributor.author	Filipkowski, Robert K.
dc.contributor.author	Wawrzyniak, Marcin
dc.contributor.author	Lioudyno, Victoria
dc.contributor.author	Knapska, Ewelina
dc.contributor.author	Gorkiewicz, Tomasz
dc.contributor.author	Balcerzyk, Marcin
dc.contributor.author	Leski, Szymon
dc.contributor.author	Van Leuven, Fred
dc.contributor.author	Lipp, Hans-Peter
dc.contributor.author	Wójcik, Daniel K.
dc.contributor.author	Kaczmarek, Leszek
dc.date	2011
dc.identifier.citation	Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Curr Alzheimer Res. 2011;8(8):883-92. DOI: 10.2174/156720511798192745
dc.identifier.citation	1567-2050
dc.identifier.citation	http://dx.doi.org/10.2174/156720511798192745
dc.identifier.uri	http://hdl.handle.net/10230/35238
dc.description.abstract	In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
dc.description.abstract	This work was supported by MemStick grant (7 Frame-work Program of EU), the NCCR “Neural Plasticity and Re-pair” and Swiss National Science Foundation.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Bentham Science Publishers
dc.relation	Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© Bentham Science Publishers. Article published in Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/89141/article
dc.subject	Circadian rhythm
dc.subject	Group learning
dc.subject	Individual learning
dc.subject	IntelliCage
dc.subject	Social behavior
dc.subject	Amyloid precursor protein
dc.subject	IntelliCage system
dc.subject	Ageing
dc.subject	Sensorimotor
dc.title	Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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