Use this identifier to quote or link this document: http://hdl.handle.net/2072/356053

Title:	Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules
Author:	Guo, Wusheng; Laserna, Victor; Rintjema, Jeroen; Kleij, Arjan W.
Abstract:	Oxetanes are versatile building blocks in drug- related synthesis to induce property-modulating effects. Whereas related oxiranes are widely used in coupling chemistry with carbon dioxide (CO2) to afford value-added commodity chemicals, oxetanes/CO2 couplings remain extremely limited despite the recent advances in the synthesis of these four-membered heterocycles. Here we report an effective one-pot three-component reaction (3CR) strategy for the coupling of (substituted) oxetanes, amines and CO2 to afford a variety of functionalized carbamates with excellent chemo-selectivity and good yields. The process is mediated by an aluminium based catalysts under relatively mild conditions and the developed catalytic methodology can be applied to the formal synthesis of two pharmaceutically relevant carbamates with the 3CR being a key step.
Publication date:	2016-05-19
Subject(s):	54
Rights:	L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/
Pages:	1602 p.
Document type:	Article Article - Accepted version
DOI:	10.1002/adsc.201500895|
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