Título:
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A Domino Process towards Functionally Dense Quaternary Carbons through Pd-Catalyzed Decarboxylative Csp3-Csp3 Bond Formation
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Autor/a:
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Guo, Wusheng; Kuniyil, Rositha; Gómez, José Enrique; Maseras, Feliu; Kleij, Arjan W.
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Abstract:
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An efficient protocol was developed to construct functionally dense quaternary carbons with concomitant formation of a new Csp3-Csp3 bond via Pd-catalyzed decarboxylative transformation of vinyl cyclic carbonates. This redox neutral catalytic system features stereocontrolled formation of multi-substituted allylic scaffolds with an aldehyde functionality generated in situ, and it typically can be performed at room temperature without any additives. DFT calculations provide a rationale towards the selective formation of these compounds, and revealed a complex mechanism that is able to reproduce with the help of microkinetic models the non-trivial dependence between the identity of the product and the nature of the substituents in the substrate. |
Fecha de creación:
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16-01-2018 |
Materia(s):
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54 |
Derechos:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Páginas:
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3981 p. |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
DOI:
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10.1021/jacs.7b12608
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Compartir:
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