dc.contributor.author |
Guo, Wusheng |
dc.contributor.author |
Kuniyil, Rositha |
dc.contributor.author |
Gómez, José Enrique |
dc.contributor.author |
Maseras, Feliu |
dc.contributor.author |
Kleij, Arjan W. |
dc.date.accessioned |
2019-05-24T09:49:58Z |
dc.date.available |
2019-05-24T09:49:58Z |
dc.date.issued |
2018-01-16 |
dc.identifier.uri |
http://hdl.handle.net/2072/356262 |
dc.format.extent |
3981 p. |
dc.language.iso |
eng |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
54 |
dc.title |
A Domino Process towards Functionally Dense Quaternary Carbons through Pd-Catalyzed Decarboxylative Csp3-Csp3 Bond Formation |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.embargo.terms |
12 mesos |
dc.identifier.doi |
10.1021/jacs.7b12608 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
An efficient protocol was developed to construct functionally dense quaternary carbons with concomitant formation of a new Csp3-Csp3 bond via Pd-catalyzed decarboxylative transformation of vinyl cyclic carbonates. This redox neutral catalytic system features stereocontrolled formation of multi-substituted allylic scaffolds with an aldehyde functionality generated in situ, and it typically can be performed at room temperature without any additives. DFT calculations provide a rationale towards the selective formation of these compounds, and revealed a complex mechanism that is able to reproduce with the help of microkinetic models the non-trivial dependence between the identity of the product and the nature of the substituents in the substrate. |