Abstract:
|
We describe the recent emergence of a new approach for the synthesis of
cyclopropane rings by means of photoredox catalysis. This methodology relies
on the photocatalytic generation of radical carbenoids or carbenoid-like
radicals as cyclopropanating species, and its characterized by an excellent
functional group tolerance, chemoselectivity and ability to cyclopropane E/Z
alkene mixtures with excellent stereocontrol. The mild reaction conditions and
the employ of user-friendly reagents are highly attractive features that may
find immediate use in academic and industrial laboratories. |