Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning 

Lao, Oscar; Acosta, Sandra; Turpin, Isabel; Modrego, Adriana; Martí Sarrias, Andrea; Ortega Gascó, Alba; Haeb, Anna-Christina; García González, Laura; Soriano i Fradera, Jordi; Ruiz, Núria; Peñuelas Haro, Irene; Espinet, Elisa; Tornero, Daniel (2025-12-16)

Dravet syndrome (DS) is a developmental epileptic encephalopathy (DEE) driven by pathogenic variants in the SCN1A gene. Brain organoids (BOs) have emerged as reliable models for neurodevelopmental genetic disorders, ...

Brain–gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation 

Sancho Balsells, Anna; Borràs Pernas, Sara; Flotta, Francesca; Chen, Wanqi; Toro, Daniel del; Rodríguez Allué, Manuel José; Alberch i Vié, Jordi, 1959-; Blivet, Guillaume; Touchon, Jacques; Xifró i Collsamata, Xavier; Giralt Torroella, Albert (2025-11-28)

Background: Chronic stress is an important risk factor for the development of major depressive disorder (MDD). Recent studies have shown microbiome dysbiosis as one of the pathogenic mechanisms associated with MDD. Thus, ...

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice 

Portolés, Irene; Ribera, Jordi; Fernández Galán, Esther; Lecue Costas, Elena; Casals Mercadal, Gregori; Melgar Lesmes, Pedro; Fernández Varo, Guillermo; Boix i Ferrero, Loreto; Sanduzzi Zamparelli, Marco; Aishwarya, Veenu; Reig, María; Jiménez Povedano, Wladimiro; Morales Ruiz, Manuel (2025-08-27)

RNA helicase DHX15 plays a significant role in vasculature development and lung metastasis in vertebrates. In addition, several studies have demonstrated the overexpression of DHX15 in the context of hepatocellular carcinoma. ...

Andronet News. Winter 2022/2023 

Rajpert-De Meyts, Ewa (2025-11-10)

After the Holiday Season at the end of 2022, followed by January ‘hibernation’, we are beginning to work towards the objectives of our Action

MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway. 

Guo, Yanru; Ollé, Laia; Proaño Pérez, Elizabeth; Aparicio, Cristina; Guerrero, Miguel; Muñoz Cano, Rosa Maria; Martín Andorrà, Margarita (2025-01-29)

MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate ...

Anatomical landmarks localization for capsule endoscopy studies 

Laiz Treceño, Pablo; Vitrià i Marca, Jordi; Gilabert Roca, Pere; Wenzek, Hagen; Malagelada Grau, Cristina; Watson, Angus J. M.; Seguí Mesquida, Santi (2024-02-22)

Wireless Capsule Endoscopy is a medical procedure that uses a small, wireless camera to capture images of the inside of the digestive tract. The identification of the entrance and exit of the small bowel and of the large ...

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodelling of both postsynaptic density and NMDA receptor signalling 

Torres Peraza, Jesús Fernando; Giralt Torroella, Albert; García Martínez, Juan M.; Pedrosa, Edurne; Canals i Coll, Josep M.; Alberch i Vié, Jordi (2024-02-16)

We study the striatal susceptibility to NMDA receptor (NMDAR)-</p><p>mediated injury of two Huntington’s disease (HD) transgenic mice:</p><p>R6/1 and R6/1:BDNF+/−. We found that R6/1:BDNF+/− mice – which</p><p>express ...

Cortical thickness modeling and variability in Alzheimer's disease and frontotemporal dementia. 

Pérez Millan, Agnès; Borrego Écija, Sergi; Falgàs Martínez, Neus; Juncà Parella, Jordi; Bosch Capdevila, Beatriz; Tort Merino, Adrià; Antonell, Anna; Bargalló Alabart, Núria; Rami González, Lorena; Balasa, Mircea; Lladó Plarrumaní, Albert; Sala Llonch, Roser; Sánchez Valle, Raquel (2025-03-27)

Background and objective: Alzheimer's disease (AD) and frontotemporal dementia (FTD) show different patterns of cortical thickness (CTh) loss compared with healthy controls (HC), even though there is relevant heterogeneity ...

Aberrant TIMP-1 production in tumor-associated fibroblasts drives the selective benefits of nintedanib in lung adenocarcinoma 

Teixido, Cristina; Fernández Nogueira, Patricia; Galbis, José Marcelo; Alcaraz, Jordi; Duch, Paula; Díaz Valdivia, Natalia; Gabasa Ferràndez, Marta; Ikemori, Rafael; Arshakyan, Marselina; Llorente, Alejandro; Ramírez, Josep; Pereda, Javier; Chuliá Peris, Lourdes; Hilberg, Frank; Reguart, Noemí; Radisky, Derek C; Alcaraz, Jordi (2025-01-27)

The fibrotic tumor microenvironment is a pivotal therapeutic target. Nintedanib, a clinically approved multikinase antifibrotic inhibitor, is effective against lung adenocarcinoma (ADC) but not squamous cell carcinoma ...

Selective metabolic regulations by p53 mutant variants in pancreatic cancer 

Caporali, Sabrina; Butera, Alessio; Ruzza, Alessia; Zampieri, Carlotta; Bantulà, Marina; Scharsich, Sandra; Ückert, Anna-Katerina; Celardo, Ivana; Kouzel, Ian U.; Leanza, Luigi; Gruber, Andreas; Montero Boronat, Joan; D'Alessandro, Angelo; Brunner, Thomas; Leist, Marcel; Amelio, Ivano (2025-03-06)

Background: Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting ...

Genomic programming of human neonatal dendritic cells in congenital systemic and in vitro cytomegalovirus infection reveal plastic and robut immune pathway biology responses 

Dantoft, Widad; Martínez Vicente, Pablo; Jafali, James; Pérez Martínez, Lara; Martin, Kimberly; Kotzamanis, Konstantinos; Craigon, Marie; Auer, Manfred; Young, Neil T.; Walsh, Paul; Marchant, Arnaud; Angulo Aguado, Ana; Forster, Thorsten; Ghazal, Peter (2019-08-28)

Neonates and especially premature infants are highly susceptible to infection but still can have a remarkable resilience that is poorly understood. The view that neonates have an incomplete or deficient immune system is ...

AMEE Conference: de Glasgow 2015 a Barcelona 2016 [Editorial] 

Palés, J. L. (Jorge Luis) (2016-11-14)

La Association for Medical Education in Europe (AMEE), fundada en 1972 por iniciativa de diferentes sociedades nacionales de educación médica- entre ellas la Sociedad Española de Educación Médica (SEDEM)-, viene celebrando ...

Molecular Games, una herramienta de aprendizaje autónomo y gamificado de biología molecular 

Saura Martí, Josep; Santalucía Albi, Tomàs; Martí, E.; Straccia, Marco (2019-10-04)

Standardized nanomechanical atomic force microscopy procedure (SNAP) for measuring soft and biological samples 

Schillers, Hermann; Rianna, Carmela; Schape, Jens; Luque González, Tomás; Doschke, Holger; Walte, Mike; Uriarte, Juan José; Campillo, Noelia; Michanetzis, Georgios P. A.; Bobrowska, Justyna; Dumitru, Andra; Herruzo, Elena T.; Bovio, Simone; Parot, Pierre; Galluzzi, Massimiliano; Podestà, Alessandro; Puricelli, Luca; Scheuring, Simon; Missirlis, Yannis; Garcia, Ricardo; Odorico, Michael; Teulon, Jean-Marie; Lafont, Frank; Lekka, Malgorzata; Rico Camps, Félix; Rigato, Annafrancesca; Pellequer, Jean-Luc; Oberleithner, Hans; Navajas Navarro, Daniel; Radmacher, Manfred (2018-11-28)

We present a procedure that allows a reliable determination of the elastic (Young's) modulus of soft samples, including living cells, by atomic force microscopy (AFM). The standardized nanomechanical AFM procedure (SNAP) ...

M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus 

Conde-Berriozábal, Sara; García Gilabert, Lia; García-García, Esther; Sitjà Roqueta, Laia; López Gil, Xavier; Muñoz-Moreno, Emma; Boutagouga Boudjadja, Mehdi; Soria, Guadalupe; Rodríguez Allué, Manuel José; Alberch i Vié, Jordi, 1959-; Masana Nadal, Mercè (2023-09-14)

Early and progressive cortico-striatal circuit alterations have been widely characterized in Huntington's disease (HD) patients. Cortical premotor area, M2 cortex in rodents, is the most affected cortical input to the ...

CDK9 inhibition as an effective therapy for small cell lung cancer 

Valdez Capuccino, L.; Kleitke, T.; Szokol, B.; Svajda, L.; Martin, F.; Bonechi, F.; Kreko, M.; Azami, S.; Montinaro, A.; Wang, Yan; Nikolov, V.; Kaiser, L.; Bonasera, D.; Saggau, J.; Scholz, T.; Schmitt, A.; Beleggia, F.; Reinhardt, H. C.; George, J.; Liccardi, G.; Walczak, H.; Tovari, J.; Braegelmann, J.; Montero, J.; Sos, M. L.; Orfi, L.; Peltzer, N. (2025-03-05)

Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin and etoposide recently combined with PD-L1 inhibitors. Yet, in most cases, SCLC patients develop ...

La Facultad de Medicina de la Universidad de Murcia espera a todos los educadores en ciencias de la salud en el XXII Congreso de la SEDEM 

Gual Sala, Arcadi (2017-01-24)

Since it was founded, the principal line of action of the Fundación Educación Médica (FEM) has been the incorporation and di usion of the know-how that is generated around the world in the area of medical education. To ...

Biomarkers predicting antidepressant treatment response - how can we advance the field? 

Labermaier, Christiana; Masana Nadal, Mercè; Müller, Marianne B. (2024-01-29)

Major depression, affecting an estimated 350 million people worldwide, poses a serious social and economic threat to modern societies. There are currently two major problems calling for innovative research approaches, ...

Resveratrol attenuates intermittent hypoxia-induced macrophage migration to visceral white adipose tissue and insulin resistance in male mice. 

Carreras, Alba; Zhang, Shelley X.L.; Almendros López, Isaac; Wang, Yang; Peris, Eduard; Qiao, Zhuanhong; Gozal, David (2016-09-21)

Chronic intermittent hypoxia during sleep (IH), as occurs in sleep apnea, promotes systemic insulin resistance. Resveratrol (Resv) has been reported to ameliorate high-fat diet-induced obesity, inflammation, and insulin ...

Bolonia en las facultades de medicina españolas, seis años después: algunas preguntas para la reflexión 

Palés, J. L. (Jorge Luis) (2017-04-24)

En el año 2009, la gran mayoría de las facultades de medicina españolas ponían en marcha sus nuevos planes de estudios, adaptados a lo que hemos venido denominando Espacio Europeo de Educación Superior o proceso de ...