Bioquímica i Biomedicina Molecular: Recent submissions
Now showing items 741-760 of 918
Prediction and validation of protein intermediate states from structurally rich ensembles and coarse grained simulations
Protein conformational changes are at the heart of cell functions, from signalling to ion transport. However, the transient nature of the intermediates along transition pathways hampers their experimental detection, making ...
Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skeletal ...
An Escape-Room about Krebs cycle prepared for Chemical Students
Games are excellent teaching tools for self-learning. Students playing a game enjoy themselves and at the same time learn basic and important concepts. Different games including crossword puzzles, word search puzzles, ...
The anomeric nature of glucose and its implications on its analyses and the influence of diet: are routine glycaemia measurements reliable enough?
Background: Glucose is the main inter-organ energy supplying metabolite in humans and other vertebrates. In clinical analyses, its measurement is probably the most performed and used for diagnostic, monitoring and control ...
Cannabinoid receptors CB1 and CB2 form functional heteromers in the brain
Exploring the role of cannabinoid CB2 receptors in the brain, we present evidence of CB2 receptor molecular and functional interaction with cannabinoid CB1 receptors. Using biophysical and biochemical approaches, we ...
Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism
The composition of extracellular vesicles (EVs) is altered in many pathological conditions, and their molecular content provides essential information on features of parent cells and mechanisms of crosstalk between cells ...
BioExcel Building Blocks Workflows (BioBB-Wfs), an integrated web-based plartform for biomolecular simulations.
We present BioExcel Building Blocks Workflows, a web-based graphical user interface (GUI) offering access to a collection of transversal pre-configured biomolecular simulation workflows assembled with the BioExcel Building ...
Recursos ben dirigits
L'assignatura pendent dels diferents governs és saber destinar els recursos als llocs adients i en la quantitat suficient. Sovint s'ha encertat en el lloc però l'import ha estat massa petit i els diners no han produït ...
Difining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case
The early stages of the thermal unfolding of apoflavodoxin have been determined by using atomistic multi microsecond-scale molecular dynamics (MD) simulations complemented with a variety of experimental techniques. Results ...
Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
Background and hypothesis: Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and ...
Untargeted metabolomics reveals distinct metabolic reprogramming in endothelial cells co-cultured with CSC and non-CSC prostate cancer cell subpopulations.
Tumour angiogenesis is an important hallmark of cancer and the study of its metabolic adaptations, downstream to any cellular change, can reveal attractive targets for inhibiting cancer growth. In the tumour microenvironment, ...
Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells
Background PPP1R6 is a protein phosphatase 1 glycogen-targeting subunit (PP1-GTS) abundant in skeletal muscle with an undefined metabolic control role. Here PPP1R6 effects on myotube glycogen metabolism, particle size and ...
Design, Synthesis, and Biological Evaluation of Novel Urea-Containing Carnosic Acid Derivatives with Anticancer Activity
A series of novel carnosic acid 1 derivatives incorporating urea moieties at the C-20 position was synthesized and evaluated for their antiproliferative activity against the HCT116 colorectal cancer cell line. Most derivatives ...
The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells
AIMS: Mitofusin-2 (Mfn2) expression is dysregulated in vascular proliferative disorders and its overexpression attenuates the proliferation of vascular smooth muscle cells (VSMCs) and neointimal lesion development after ...
Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
Antagonistic and reciprocal interactions are known to exist between adenosine and dopamine receptors in the striatum. In the present study, double immunofluorescence experiments with confocal laser microscopy showed a high ...
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented but the mechanism underlying this ...
Maslinic acid, a natural Triterpene, induces a death receptor-mediated apoptotic mechanism in Caco-2 p53-deficient colon adenocarcinoma cells
Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mito- chondrial apoptotic pathway in HT29 colon ...
La Universitat ens ajudarà a sortir de la crisi?
La Universitat no ha de ser un centre de formació professional, i en general no prepara per professions específiques, però sí que pot afavorir l'adquisició d'eines necessàries en el món professional, entre les quals l'esperit ...
Rat splanchnic net oxygen consumption. Energetic implications
1. The blood flow, PO2, pH and PCO2 have been estimated in portal and suprahepatic veins as well as in hepatic artery of fed and overnight starved rats given an oral glucose load. From these data the net intestinal, hepatic ...
