Bioquímica i Biomedicina Molecular: Envíos recientes
Mostrando ítems 21-40 de 920
Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia
Cancer patients commonly suffer from cachexia, a syndrome in which tumors induce metabolic changes in the host that lead to massive loss in skeletal muscle mass. Using a preclinical mouse model of cancer cachexia, we tested ...
Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds
Arabidopsis thaliana contains two genes encoding farnesyl diphosphate (FPP) synthase (FPS), the prenyl diphoshate synthase that catalyzes the synthesis of FPP from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate ...
Modulation of rat liver urea cycle and related ammonium metabolism by sex and cafeteria diet
High-energy (hyperlipidic) cafeteria diets induce insulin resistance limiting glucose oxidation, and lower amino acid catabolism. Despite high amino-N intake, amino acids are preserved, lowering urea excretion. We analysed ...
A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease
Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an ...
Cannabinoid receptors CB1 and CB2 form functional heteromers in the brain
Exploring the role of cannabinoid CB2 receptors in the brain, we present evidence of CB2 receptor molecular and functional interaction with cannabinoid CB1 receptors. Using biophysical and biochemical approaches, we ...
Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression.
Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart. It appears to be involved in metabolic handling of fatty acids in a way that minimizes ...
De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition
Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 ...
Adenosine A2A receptors and A2A receptor heteromers as key players in striatal function
A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum, where they are preferentially localized postsynaptically in striatopallidal medium spiny neurons (MSNs). In this localization A2ARs ...
Oleoyl-estrone is a precursor of an estrone-derived ponderostat signal
Oleoyl-estrone (OE) is a powerful anti-obesity compound that decreases food intake, decreases insulin resistance and circulating cholesterol. OE stimulates a severe loss of body fat by decreasing adipose tissue lipid ...
Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis.
The mitochondrial electron transport chain transforms energy satisfying cellular demand and generates reactive oxygen species (ROS) that act as metabolic signals or destructive factors. Therefore, knowledge of the possible ...
Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis
Flow (shear stress)-mediated dilation (FMD) of resistance arteries is a rapid endothelial response involved in tissue perfusion. FMD is reduced early in cardiovascular diseases, generating a major risk factor for ...
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate
FSP27 (CIDEC in humans) is a protein associated with lipid droplets that downregulates the fatty acid oxidation (FAO) rate when it is overexpressed. However, little is known about its physiological role in liver. Here, we ...
Com generar i finançar els nuclis d'innovació
La qüestió és com generar i finançar els nuclis d'innovació. A parer meu, la transferència, més enllà dels discursos, no és una prioritat. Les prioritats estan en els pressupostos i en l'assignació dels recursos humans. ...
A tool for the stating of cahexia in càncer patients: CAchexia SCOre (CASCO)
Projecte: AVCRI137
Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a ...
Recerca en nutrició sostenible
El que ja és evident és la creixent demanda de proteïna vegetal per substituir la carn. Només cal veure com molts supermercats han condicionat seccions dedicades a l'alimentació vegetariana on es poden trobar aquests ...
La legislatura de la Ciència Oberta
Necessitem una plataforma intel·ligent, capaç de gestionar la informació, amb experts, que ofereixi una manera eficient de navegar pels recursos, la tecnologia i les capacitats d'innovació que hi ha en l'ecosistema d'innovació ...
Protein interaction studies point to new functions for Escherichia coli glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is considered a multifunctional protein with defined functions in numerous mammalian cellular processes. GAPDH functional diversity depends on various factors such as covalent ...
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
BACKGROUND: G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers ...
Cancer-Associated Fibroblasts in breast cancer treatment response and metastasis.
Breast cancer (BrCa) is the leading cause of death among women worldwide, with about one million new cases diagnosed each year. In spite of the improvements in diagnosis, early detection and treatment, there is still a ...
