Bioquímica i Biomedicina Molecular: Envíos recientes
Mostrando ítems 641-660 de 919
Effects of adult dysthyroidism on the morphology of hippocampal neurons.
This study investigates the effect of thyroid hormones on the morphology of hippocampal neurons in adult rats. Hypo- and hyperthyroidism were induced by adding 0.02% methimazole and 1% l-thyroxine, in drinking water from ...
Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells
Carnitine palmitoyltransferase 1 (CPT1) catalyzes the first step in long-chain fatty acid import into mitochondria, and it is believed to be rate limiting for beta-oxidation of fatty acids. However, in muscle, other proteins ...
Theophylline is able to partially revert cachexia in tumour-bearing rats
Background and aims: the aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia. Methods: the in vitro effects of ...
Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages
Voltage-dependent K+ channels (VDPC) are expressed in most mammalian cells and involved in the proliferation and activation of lymphocytes. However, the role of VDPC in macrophage responses is not well established. This ...
Optimal management of cancer cachexia-anorexia syndrome
According to a recent consensus, cachexia is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. The prominent clinical feature of cachexia ...
Redox balance and carbonylated protein in limb muscles and heart of cachectic rats
In fast- and slow-twitch limb and heart muscles of cachectic rats, redox balance and muscle structure were explored. The nature of the oxidatively modified proteins also was identified in these muscles. Reactive carbonyls, ...
Alanine aminotransferase: A target to improve utilisation of dietary nutrients in aquaculture
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430
Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics
Understanding the trafficking of G-protein-coupled receptors (GPCRs) and their regulation by agonists and antagonists is fundamental to develop more effective drugs. Optical methods using fluorescent-tagged receptors and ...
Heteromerization between α2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
Polymorphic alleles of the human dopamine D4 receptor gene (DRD4) have been consistently associated with individual differences in personality traits and neuropsychiatric disorders, particularly between the gene encoding ...
Transport de nucleòsids
La presència de transportadors específics per a nucleòsids ha estat descrita en nombrosos tipus cel·lulars. Els factors que justifiquen l'existencia d'aquests transportadors son diversos..
Characterization of two distinct intracellular GLUT4 membrane populations in muscle fiber: differential protein composition and sensivity to insulin
A major objective for the understanding of muscle glucose disposal is the elucidation of the intracellular trafficking pathway of GLUT4 glucose carriers in the muscle fiber. In this report, we provide functional and ...
Regulation of nucleoside transport regulation by lipopolysaccharide, phorbol esters and TNF in human B lymphocytes
Nucleoside transport systems and their regulation in human B-lymphocytes have been characterized using the cell lines Raji and Bare lymphoma syndrome-1 (BLS-1) as experimental models. These cells express at least three ...
Inhibition of human enhancer of zeste homolog 2 with tambjamine analogs
Combining computational modeling, de novo compound synthesis, and in vitro and cellular assays, we have performed an inhibition study against the enhancer of zeste homolog 2 (EZH2) histone-lysine N-methyltransferase. This ...
Adenosine receptor heteromers and their integrative role in striatal function
By analyzing the functional role of adenosine receptor heteromers, we review a series of new concepts that should modify our classical views of neurotransmission in the central nervous system (CNS). Neurotransmitter receptors ...
Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation
Metabotropic glutamate receptors (mGluR) are present in cells of the nervous system, where they are activated by one of the main neurotransmitters, glutamate. They are also expressed in cells outside the nervous system. ...
The adenosine A2A receptor interacts with the actin-binding protein α-actinin
Recently, evidence has emerged that heptaspanning membrane or G protein-coupled receptors may be linked to intracellular proteins identified as regulators of receptor anchoring and signaling. Using a yeast two-hybrid screen, ...
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Background It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid ...
Association of Kv1.5 and Kv1.3 contributes to the major voltage-dependent K+ channel in macrophages
Voltage-dependent K(+) (Kv) currents in macrophages are mainly mediated by Kv1.3, but biophysical properties indicate that the channel composition could be different from that of T-lymphocytes. K(+) currents in mouse bone ...
Mutations in JMJD1C are involved in Rett syndrome and intellectual disability
Purpose: autism spectrum disorders are associated with defects in social response and communication that often occur in the context of intellectual disability. Rett syndrome is one example in which epilepsy, motor impairment, ...
Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.
Transforming Growth Factor beta (TGF-β) induces tumor cell migration and invasion. However, its role in inducing metabolic reprogramming is poorly understood. Here we analyzed the metabolic profle of hepatocellular carcinoma ...
