Bioquímica i Biomedicina Molecular: Enviaments recents
Ara mostrant els elements 661-680 de 919
Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
Multiple Kv1.5 targeting to membrane surface microdomains
Surface expression of voltage-dependent K+ channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules ...
Dysfunctional LAT2 amino acid transporter is associated with cataract in mouse and humans
Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid ...
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum
The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic ...
EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor
Castration-resistant prostate cancer is the lethal condition suffered by prostate cancer patients that become refractory to androgen deprivation therapy. EPI-001 is a recently identified compound active against this condition ...
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
We combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent ...
DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region
Human mitochondrial DNA (h-mtDNA) codes for 13 subunits of the oxidative phosphorylation pathway, the essential route that produces ATP. H-mtDNA transcription and replication depends on the transcription factor TFAM, which ...
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
We analyze the physical origin and the chemical and biological consequences of the asymmetry that occurs in DNA·RNA hybrids when the purine/pyrimidine (Pu/Py) ratio is different in the DNA and RNA strands. When the DNA ...
Children as trainers on children’s rights. Our Toolbox. (ImCitizen)
IMCITIZEN (CERV-2022-CHILD)
Polymorphisms of Pyrimidine Pathway Enzymes Encoding Genes and HLA-B*40∶01 Carriage in Stavudine-Associated Lipodystrophy in HIV-Infected Patients.
Purpose To assess in a cohort of Caucasian patients exposed to stavudine (d4T) the association of polymorphisms in pyrimidine pathway enzymes and HLA-B*40∶01 carriage with HIV/Highly active antiretroviral therapy ...
Metabolic alterations in cardiopulmonary vascular dysfunction
Cardiovascular diseases (CVD) are the leading cause of death worldwide. CVD comprise a range of diseases affecting the functionality of the heart and blood vessels, including acute myocardial infarction (AMI) and pulmonary ...
The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells
AIMS: Mitofusin-2 (Mfn2) expression is dysregulated in vascular proliferative disorders and its overexpression attenuates the proliferation of vascular smooth muscle cells (VSMCs) and neointimal lesion development after ...
Anàlisi cel·lular per hibridació "in situ" i inmunolocalització de l'expressió i distribució de la lipoproteina lipasa en ovari de conills d'índies
An important ovarian function is the synthesis of steroid hormones for menstrual cycle regulation. Blood substrate for these hormones are large lipoprotein complex, unable to cross the cellular membrane without previous ...
DNA sequence of the gene encoding the Zc1 protein from Zea mays W64A
The Zein-2 component named Zc 1 corresponds to a storage protein of an apparent M.W. of 16 kDa present in maize endosperm.
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies
Combined therapies play a key role in the fight against complex pathologies, such as cancer and related drug-resistance issues. This is particularly relevant in targeted therapies where inhibition of the drug target can ...
Prevalent sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH
We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a ...
Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics
The energetics of intramolecular recognition processes are governed by the balance of pre‐organization and flexibility, which is often difficult to measure and hard to predict. Using classical MD simulations, we predict ...
Correlated motions in DNA. Beyond base-pair step models of DNA flexibility
Traditional mesoscopic models of DNA flexibility use a reductionist-local approach, which assumes that the flexibility of DNA can be expressed as local harmonic movements (at the base-pair step level) in the helical space, ...
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems
Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria ...
Evidence for transcript networks composed of chimeric RNAs in human cells
The classic organization of a gene structure has followed the Jacob and Monod bacterial gene model proposed more than 50 years ago. Since then, empirical determinations of the complexity of the transcriptomes found in yeast ...
