Ciències Fisiològiques: Envíos recientes
Mostrando ítems 1-20 de 816
Interrelation of adipose tissue macrophages and fibrosis in obesity.
Obesity is characterized by adipose tissue expansion, extracellular matrix remodelling and unresolved inflammation that contribute to insulin resistance and fibrosis. Adipose tissue macrophages represent the most abundant ...
Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3.
Myocardial ischemia-reperfusion (IR) injury may result in cardiomyocyte dysfunction. Mitochondria play a critical role in cardiomyocyte recovery after IR injury. The mitochondrial uncoupling protein 3 (UCP3) has been ...
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification
Heterotopic ossification (HO) occurs following mechanical trauma and burns, or congenitally in patients suffering from fibrodysplasia ossificans progressiva (FOP). Recently, we demonstrated that inhibitors of phosphatidylinositol ...
Diverse inhibitors of de novo purine synthesis promote AICAR-induced AMPK activation and glucose uptake in L6 myotubes
Methotrexate, an immunosuppressant and anticancer drug, promotes glucose uptake and lipid oxidation in skeletal muscle via activation of AMP-activated protein kinase (AMPK). Methotrexate promotes AMPK activation by inhibiting ...
A review of vancomycin, gentamicin and amikacin population pharmacokientic models in neonates and infants.
Abstract Population pharmacokinetic (popPK) models are an essential tool when implementing therapeutic drug monitoring (TDM) and to overcome dosing challenges in neonates in clinical practice. Since vancomycin, gentamicin, ...
Lung diffusing capacity after different modalities of exercise at sea level and hypobaric simulated altitude of 4000 m
Introduction: Lung diffusion capacity of carbon monoxide (DLCO) provides a measure of gas transfer in the lungs, which increase in relation to exercise and decrease in the presence of lung interstitial disease. The aim of ...
Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study
Introduction: Surgical procedure is the treatment of choice in early stage I lung adenocarcinoma. However, a considerable number of patients experience recurrence within the first 2 years after complete resection. Suitable ...
Biologia dels transportadors de glucosa de difusió facilitada. Redistribució cel.lular de transportadors de glucosa en resposta a hormones
La glucosa és la font d'energia més important per a les cèl·lules dels mamífers. La seva oxidació en condicions aeròbiques o anaeròbiques abasteix constantment d 'ATP les cèl·lules. Després de ]a ingesta, l'excés de glucosa ...
SSCP-polymorphism in intron 12 of the CFTR gene recognized by BclI
Source/Description: SSCP analysis of intron 12 of the CFTR gene from PCR products showed an extra band in several DNA samples. Sequencing of the additional fragment extra band revealed a T- A change in the position 1898 + ...
Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation
Atherosclerotic lesions are asymmetric focal thickenings of the intima of arteries that consist of lipids, various cell types and extracellular matrix (ECM). These lesions lead to vascular occlusion representing the most ...
Diseño de nuevos planes de estudios de medicina en el contexto del espacio europeo de educación superior. I.- Punto de partida y decisiones previas
Hasta hace poco el proceso de construcción del Espacio Europeo de Educación Superior (EEES), por lo que respecta a los estudios de Medicina, se ha desarrollado con un ritmo más lento que en el caso de otras titulaciones; ...
Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development
Wt1 encodes a zinc finger protein that is crucial for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly ...
Insuline-like effects of vanadate on glucokinase activity and fructose 2,6-bisphosphate levels in the liver of diabetic rats
Streptozotocin diabetic rats showed more than a 4-fold increase in blood glucose levels, whereas hepatic glycogen, fructose 2,6-bisphosphate concentration, and 6-phosphofructo-2-kinase activity were decreased. The 'total' ...
Rheology of passive and adhesion-activated neutrophils probed by Atomic Force Microscopy
The rheology of neutrophils in their passive and activated states plays a key role in determining their function in response to inflammatory stimuli. Atomic force microscopy was used to study neutrophil rheology by measuring ...
The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties
The methyl-CpG binding domain (MBD) family of proteins was defined based on sequence similarity in their DNA binding domains. In light of their high degree of conservation, it is of inherent interest to determine the genomic ...
The disruption of mitochondrial axonal transport is an early event in neuroinflammation
Background: in brain inflammatory diseases, axonal damage is one of the most critical steps in the cascade that leads to permanent disability. Thus, identifying the initial events triggered by inflammation or oxidative ...
A correction procedure for the asymmetry of differential pressure transducers in respiratory impedance measurements
The usual setup for measuring respiratory input impedance requires a differential pressure transducer attached to a pneumotachograph. Because no data correction procedure has been devised to account for transducer asymmetry, ...
Planificar un curriculum o un programa formativo
Un currículum o un programa de formación, sea cual sea la etapa del continuum de la educación médica en la que se inscriba, no es simplemente el contenido del mismo o el listado de las materias y asignaturas que lo componen, ...
Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis
Background Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells ...
La perspectiva americana: innovación en biomedicina
A pesar de que los tópicos mencionados se cumplen, no todas las áreas geográficas tienen la misma capacidad de innovación. Cleveland, una ciudad media entre el Midwest y el Este americano que se enorgullece de ser sede del ...
