IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer

Els materials de recerca de la Universitat de Barcelona (UB) a RECERCAT s'obtenen de les col·leccions de Recerca del Dipòsit Digital de la UB.
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Política d’accés obert a la UB


Publicacions en accés obert derivades de l'activitat investigadora del professorat de la Universitat de Barcelona.

Recent Submissions

Mediterranean Diet Pattern: Potential Impact on the Different Altered Pathways Related to Cardiovascular Risk in Advanced Chronic Kidney Disease 

Rovira, Jordi; Ramírez Bajo, María José; Bañón Maneus, Elisenda; Ventura Aguiar, Pedro; Arias Guillén, Marta; Romano Andrioni, Bárbara; Ojeda, Raquel; Revuelta, Ignacio; García Calderó, Héctor; Barberà i Mir, Joan Albert; Dantas, Ana Paula; Diaz Ricart, M. Isabel; Crispi Brillas, Fàtima; García Pagán, Juan Carlos; Campistol Plana, Josep M.; Diekmann, Fritz (2025-12-09)

Background: Cardiovascular disease (CVD) remains the most common cause of mortality in chronic kidney disease (CKD) patients. Several studies suggest that the Mediterranean diet reduces the risk of CVD due to its influence ...

Agreement and Reliability Between Tele-Assessment and In-Person Assessment of the One-Minute Sit-to-Stand Test in Patients with Chronic Respiratory Diseases 

Larrateguy, Santiago; Otto Yáñez, Matías; Bogado, Juan; Larrateguy, Luis; Barros Poblete, Marisol; Mazzucco, Guillermo; Blanco Vich, Isabel; Gimeno Santos, Elena, 1980-; Torres Castro, Rodrigo (2025-11-28)

Background/Objectives: Telemedicine has emerged as a valuable tool for overcoming access barriers in healthcare, particularly in rehabilitation. However, the validity and reliability of remotely conducted physical capacity ...

Immunoparesis defined by heavy/light chain pair suppression in smoldering multiple myeloma shows initial isotype specificity and involves other isotypes in advanced disease 

Isola, Ignacio; Moreno Fajardo, David Fernando; Moga, Esther; Mena Jaramillo, Mari Pau; Tovar Gomis, Natalia; Rodriguez Lobato, Luis Gerardo; Oliver Caldes, Aina; Salgado Martín, María del Carmen; Brasó Maristany, Fara; Yagüe Ribes, Jordi; Cibeira López, M. Teresa; Prat Aparicio, Aleix; Rosiñol Dachs, Laura; Bladé Creixenti, Joan; Fernández de Larrea Rodríguez, Carlos (2025-09-19)

Smoldering multiple myeloma (SMM) is an asymptomatic and biologically heterogeneous plasma cell disorder, with a highly variable clinical course. Immunoparesis, defined by total immunoglobulin measurements, has been shown ...

Sentinel lymph node biopsy versus pelvic lymphadenectomy for early-stage cervical cancer: a retrospective institutional review 

Marina Martín, María Tiermes; Celada Castro, Cristina; Glickman, Ariel; Carreras Dieguez, Núria; Valenzuela Rodríguez, Andrea; Fusté, Pere; Saco, Adela; Vidal i Sicart, Sergi; Torné Bladé, Aureli; Díaz Feijoo, Berta (2025-08-01)

To evaluate the oncologic and survival outcomes in patients diagnosed with early-stage cervical cancer who underwent both sentinel lymph node (SLN) and pelvic lymphadenectomy (PLD) compared with those who underwent SLN ...

A review of vancomycin, gentamicin and amikacin population pharmacokientic models in neonates and infants. 

Albanell Fernández, Marta; Bastida Fernández, Carla; Rodríguez Reyes, Montse; Soy Muner, Dolors (2025-11-07)

Abstract Population pharmacokinetic (popPK) models are an essential tool when implementing therapeutic drug monitoring (TDM) and to overcome dosing challenges in neonates in clinical practice. Since vancomycin, gentamicin, ...

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice 

Portolés, Irene; Ribera, Jordi; Fernández Galán, Esther; Lecue Costas, Elena; Casals Mercadal, Gregori; Melgar Lesmes, Pedro; Fernández Varo, Guillermo; Boix i Ferrero, Loreto; Sanduzzi Zamparelli, Marco; Aishwarya, Veenu; Reig, María; Jiménez Povedano, Wladimiro; Morales Ruiz, Manuel (2025-08-27)

RNA helicase DHX15 plays a significant role in vasculature development and lung metastasis in vertebrates. In addition, several studies have demonstrated the overexpression of DHX15 in the context of hepatocellular carcinoma. ...

Imaging Efficacy of [18F]CTT1057 PET/CT in Patients with Biochemically Recurrent Prostate Cancer: Results from GuidePath-A Phase 3, Prospective Multicenter Study 

Fanti, Stefano; Robles Barba, Javier Jesus; Behr, Spencer; Maurer, Tobias; Paredes Barranco, Pilar; Walz, Jochen; Duch, Joan; Simo Perdigo, Marc; Mainta, Ismini Charis; Bonnefoy, Pierre Benoit; Coulanges, Medge; Tang, Jun; Seigne, Christelle; Wilke, Celine; Catafau, Ana M.; Iagaru, Andrei; Aggarwal, Rahul (2025-09-25)

Improved diagnostic accuracy in patients with prostate cancer at first biochemical recurrence (BCR) with low prostate-specific antigen (PSA) levels is needed. This prospective study (GuidePath; NCT04838613) aimed to evaluate ...

Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia 

Gimenez, Neus; Tripathi, Rupal; Giró, Ariadna; Rosich, Laia; López Guerra, Mónica; López Oreja, Irene; Playa-Albinyana, Heribert; Arenas Ríos, Fabián; Mas, José Manuel; Pérez Galán, Patricia; Delgado, Julio (Delgado González); Campo Güerri, Elias; Farrés, Judith; Colomer Pujol, Dolors (2025-10-23)

Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL ...

Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets 

López Oreja, Irene; Playa-Albinyana, Heribert; Arenas Ríos, Fabián; López Guerra, Mónica; Colomer Pujol, Dolors (2025-09-26)

Chronic lymphocytic leukemia (CLL) is characterized by a high degree of genetic variability and interpatient heterogeneity. In the last decade, novel alterations have been described. Some of them impact on the prognosis ...

SF3B1 mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia 

López Oreja, Irene; Gohr, Andre; Playa-Albinyana, Heribert; Giró, Ariadna; Arenas Ríos, Fabián; Higashi, Morihiro; Tripathi, Rupal; López Guerra, Mónica; Irimia Martínez, Manuel; Aymerich Gregorio, Marta; Valcárcel Juárez, Juan; Bonnal, Sophie; Colomer Pujol, Dolors (2025-11-12)

Splicing factor 3B subunit 1 (SF3B1) is involved in pre-mRNA branch site recognition and is the target of antitumor-splicing inhibitors. Mutations in SF3B1 are observed in 15% of patients with chronic lymphocytic leukemia ...

Genome-Wide DNA Methylation in Early-Onset-Dementia Patients Brain Tissue and Lymphoblastoid Cell Lines 

Ramos Campoy, Oscar; Comas Albertí, Aina; Hervas, David; Borrego Écija, Sergi; Bosch Capdevila, Beatriz; Sandoval, Juan; Fort Aznar, Laura; Moreno Izco, Fermín; Fernández Villullas, Guadalupe; Molina Porcel, Laura; Balasa, Mircea; Lladó Plarrumaní, Albert; Sánchez del Valle Díaz, Raquel; Antonell Boixader, Anna, 1978- (2025-09-01)

Epigenetics, a potential underlying pathogenic mechanism of neurodegenerative diseases, has been in the scope of several studies performed so far. However, there is a gap in regard to analyzing different forms of early-onset ...

Pharmacological treatments for atypical depression: A systematic review and network meta-analysis of randomized controlled trials 

Fornaro, Michele; Caiazza, Claudio; Pistone, Luca; Di Lorenzo, Chiara; Crincoli, Walter; Pezone, Rosanna; Tufano, Giovanni; Oliva, Vincenzo; De Prisco, Michele ; Miola, Alessandro; Iasevoli, Felice; Vieta i Pascual, Eduard, 1963-; Solmi, Marco; De Bartolomeis, Andrea (2025-10-22)

Introduction: Atypical depression is a highly prevalent subtype that includes mood reactivity, hypersomnia, and leaden paralysis, necessitating different therapeutic approaches than melancholic depression. No network ...

Exploring the Microbiome of Diabetic Foot Ulcers: A Focus on Cases with a Clinical Worse Outcome 

Soldevila-Boixader, Laura; Carrera Salinas, Anna; Mur, Isabel; Morata, Laura; Rivera, Alba; Bosch Mestres, Jordi; Montero Saez, Abelardo; Martínez Castillejo, Jéssica; Benito, Natividad; Martí Martí, Sara; Murillo Rubio, Óscar (2025-09-03)

Background/Objectives: We evaluated the diabetic foot ulcer (DFU) microbiome in clinical situations identified as risk factors for a worse outcome and explored the roles of the most abundant microorganisms. Methods: A ...

Cognitive symptoms in schizophrenia: an analysis of awareness, assessment, and management practices among psychiatrists and primary care physicians 

Agüera Ortiz, Luis; Aragonès, Enric; Buch Vicente, Bárbara; Mendive, Juan Manuel; Peña Granger, Mercedes; Vieta i Pascual, Eduard, 1963- (2025-10-22)

Introduction: Cognitive symptoms contribute to the worsening of functionality in people with schizophrenia. The objective of this study was to explore the current knowledge about cognitive symptoms (relevance, evaluation, ...

Cognitive and motor improvement after retesting in normal-pressure hydrocephalus: a real change or merely a learning effect? 

Solana Díaz, Elisabeth; Poca Pastor, María Antonia; Sahuquillo, Juan; Benejam, Bessy; Junqué i Plaja, Carme, 1955-; Dronavalli, Mithilesh (2025-09-26)

Object The test-retest method is commonly used in the management of patients with normal-pressure hydrocephalus (NPH). One of the most widely used techniques in the diagnosis of this condition is evaluation of the patient's ...

The PADRIS-PRESTO Cohort: A Comprehensive Population-Based Study on Mental Health in Catalonia 

De Prisco, Michele; Oliva, Vincenzo; Fico, Giovanna; Mas, Ariadna; Valenzuela-Pascual, Clàudia; Montejo Egido, Laura; Bort, Marta; Sommerhof, Constanza; Bortolozzi, Analia; Miquel Rio, Lluís; Vilella, Elisabet; Forte, Maria Florencia; Fortea, Lydia; Fernández-Plaza, Tábatha; Giménez Palomo, Anna; Sagué-Vilavella, Maria; Madero Gómez, Santiago; Llorca-Bofí, Vicent; Bioque Alcázar, Miquel; Grande i Fullana, Iria; Murru, Andrea; Pacchiarotti, Isabella; Cavero Álvarez, Myriam; Blanch Andreu, Jordi; Viñas-Bardolet, Clara; Aparicio-Nogué, Vicenç; Martínez-Cerdá, Juan Francisco; Parellada Rodón, Eduard; Martínez-Arán, Anabel, 1971-; Radua, Joaquim; Vieta i Pascual, Eduard, 1963-; Hidalgo Mazzei, Diego; Anmella, Gerard (2025-11-10)

Background: Mental disorders affect nearly 970 million people worldwide, impacting individuals and healthcare systems. Large population databases offer insights often unattainable in smaller studies, but their findings may ...

Life’s Simple 7 and Risk of Peripheral Artery Disease: Results from the PREDIMED Study and an Updated Meta-Analysis 

López Laguna, Nieves; Toledo Atucha, Estefanía; Hershey, María S.; Babio, Nancy; Sorlí, José V.; Ros Rahola, Emilio; Muñoz Pérez, Miguel Ángel; Estruch Riba, Ramon; Lapetra, José; Muñoz Bravo, Carlos; Fiol Sala, Miguel; Bautista Castaño, Inmaculada; Pintó Sala, Xavier; Ortega Azorín, Carolina; Hernando Redondo, Javier; Salas Salvadó, Jordi; Tojal Sierra, Lucas; Martínez-González, Miguel Ángel, 1957-; Ruiz Canela, Miguel (2025-09-08)

Background: Peripheral artery disease (PAD) is a major vascular condition often overlooked in prevention strategies. We aimed to evaluate the association between cardiovascular health, measured by Life's Simple 7 (LS7), ...

Resting-state functional magnetic resonance imaging activity and connectivityand cognitive outcome in traumatic brain injury 

Palacios, Eva M.; Sala Llonch, Roser; Junqué i Plaja, Carme, 1955-; Roig Rovira, María Teresa; Tormos, José María; Bargalló Alabart, Núria; Vendrell i Gómez, Pere (2025-09-15)

Importance The study of brain activity and connectivity at rest provides a unique opportunity for the investigation of the brain substrates of cognitive outcome after traumatic axonal injury. This knowledge may contribute ...

MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway. 

Guo, Yanru; Ollé, Laia; Proaño Pérez, Elizabeth; Aparicio, Cristina; Guerrero, Miguel; Muñoz Cano, Rosa Maria; Martín Andorrà, Margarita (2025-01-29)

MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate ...

Intergenerational effects of maternal childhood maltreatment on newborns' stress regulation: The role of maternal depressive symptoms 

San Martín-Gonzalez, Nerea; Moya-Higueras, Jorge; Eixarch Roca, Elisenda; Castro-Quintas, Águeda; Marques-Feixa, Laia; Crispi Brillas, Fàtima; Daura-Corral, Maria; de la Fuente-Tomás, Lorena; Monteserín-García, José Luis; García Portilla, María Paz; Fañanás Saura, Lourdes (2024-12-03)

Background: Maternal childhood maltreatment (CM) has been repeatedly associated with negative offspring's emotional outcomes. The dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis has emerged as the main ...

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