Institut de Bioenginyeria de Catalunya (IBEC): Enviaments recents
Ara mostrant els elements 1-20 de 654
Mapping mechanical stress in curved epithelia of designed size and shape
The function of organs such as lungs, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. To adopt shapes such as spheres, tubes and ellipsoids, epithelia generate mechanical stresses ...
Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms
Historical processes in community assembly, such as species arrival order, influence interactions, causing priority effects. Candida albicans and Pseudomonas aeruginosa often co-occur in biofilm-based infections of the ...
The minimal chemotactic cell
The movement of cells and microorganisms in response to chemical gradients (chemotaxis) has played an essential role in the evolution of many biological processes. Cellular navigation works via the holistic assembly of ...
Thermoplasmonic Polymersome Membranes by In Situ Synthesis
Thermoplasmonic nanoparticles, known for releasing heat upon illumination, find diverse applications in catalysis, optics, and biomedicine. Incorporating plasmonic metals within organic vesicle membranes can lead to the ...
Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
3D printing has emerged as a transformative technology in several manufacturing processes, being of particular interest in biomedical research for allowing the creation of 3D structures that mimic native tissues. The process ...
Extracellular vesicles secreted by triple-negative breast cancer stem cells trigger premetastatic niche remodeling and metastatic growth in the lungs
Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the premetastatic niche (PMN) to support cancer cell engraftment and metastatic growth. ...
Robot regulatory behaviour based on fundamental homeostatic and allostatic principles
Animals in their ecological context behave not only in response to external events, such as opportunities and threats but also according to their internal needs. As a result, the survival of the organism is achieved through ...
In vitro self-organized mouse small intestinal epithelial monolayer protocol
Developing protocols to obtain intestinal epithelial monolayers that recapitulate in vivo physiology to overcome the limitations of the organoids’ closed geometry has become of great interest during the last few years. ...
A super-resolution and transmission electron microscopy correlative approach to study intracellular trafficking of nanoparticles
Nanoparticles (NPs) are used to encapsulate therapeutic cargos and deliver them specifically to the target site. The intracellular trafficking of NPs dictates the NP-cargo distribution within different cellular compartments, ...
Liposomal sprays for nasal vaccination: a comparative study of cationic and anionic formulations involving stability upon nebulization, sprayability, and in vitro immune activation
Nasal immunization is a promising non-invasive route, enabling needle-free self-administration and activating immune cells in the mucosal tissue of the upper airways. This vaccination method is particularly appealing ...
Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
Over the past decades, the development of nanoparticles (NPs) to increase the efficiency of clinical treatments has been subject of intense research. Yet, most NPs have been reported to possess low efficacy as their actuation ...
Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices
The mechanical properties of the extracellular matrix (ECM)–a complex, 3D, fibrillar scaffold of cells in physiological environments–modulate cell behavior and can drive tissue morphogenesis, regeneration, and disease ...
Engineered Macroscale Cardiac Constructs Elicit Human Myocardial Tissue-like Functionality
In vitro surrogate models of human cardiac tissue hold great promise in disease modeling, cardiotoxicity testing, and future applications in regenerative medicine. However, the generation of engineered human cardiac ...
Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts
Genome editing on human pluripotent stem cells (hPSCs) together with the development of protocols for organ decellularization opens the door to the generation of autologous bioartificial hearts. Here we sought to generate ...
Challenging the Boundaries of the Physical Self: Distal Cues Impact Body Ownership
The unique ability to identify one's own body and experience it as one's own is fundamental in goal-oriented behavior and survival. However, the mechanisms underlying the so-called body ownership are yet not fully understood. ...
Revealing Fast Cu-Ion Transport and Enhanced Conductivity at the CuInP2S6-In4/3P2S6 Heterointerface
Van der Waals layered ferroelectrics, such as CuInP2S6 (CIPS), offer a versatile platform for miniaturization of ferroelectric device technology. Control of the targeted composition and kinetics of CIPS synthesis, enables ...
Modeling Biochemical Gradients In Vitro to Control Cell Compartmentalization in a Microengineered 3D Model of the Intestinal Epithelium
Gradients of signaling pathways within the intestinal stem cell (ISC) niche are instrumental for cellular compartmentalization and tissue function, yet how are they sensed by the epithelium is still not fully understood. ...
Dynamic photopolymerization produces complex microstructures on hydrogels in a moldless approach to generate a 3D intestinal tissue model
Epithelial tissues contain three-dimensional (3D) complex microtopographies that are essential for proper performance. These microstructures provide cells with the physicochemical cues needed to guide their self-organization ...
Insights into the structure and nanomechanics of a quatsome membrane by force spectroscopy measurements and molecular simulation
Quatsomes (QS) are unilamellar nanovesicles constituted by quaternary ammonium surfactants and sterols in defined molar ratios. Unlike conventional liposomes, QS are stable upon long storage such as for several years, they ...
