Institut de Bioenginyeria de Catalunya (IBEC): Enviaments recents
Ara mostrant els elements 21-40 de 654
Facile fabrication of mesoporous silica micro-jets with multi-functionalities
Self-propelled micro/nano-devices have been proved as powerful tools in various applications given their capability of both autonomous motion and on-demand task fulfilment. Tubular micro-jets stand out as an important ...
In silico study of substrate chemistry effect on the tethering of engineered antibodies for SARS-CoV-2 detection: Amorphous silica vs gold
The influence of the properties of different solid substrates on the tethering of two antibodies, IgG1-CR3022 and IgG1-S309, which were specifically engineered for the detection of SARS-CoV-2, has been examined at the ...
Pegylated-liposomes increase the efficacy of Idelalisib in lymphoma B-cells
New drugs and technologies are continuously developed to improve the efficacy and minimize the critical side effects of cancer treatments. The present investigation focuses on the development of a liposomal formulation for ...
Efficient One-Pot Preparation of Thermoresponsive Polyurethanes with Lower Critical Solution Temperatures
This work reports a simple and scalable strategy to prepare a series of thermoresponsive polyurethanes synthesized via copolymerization of dicyclohexyl diisocyanate with glycerol ethoxylate in a single one-pot system. These ...
OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity
OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group ...
Human induced pluripotent stem cell-derived kidney organoids toward clinical implementations
The generation of kidney organoids from human pluripotent stem cells (hPSCs) has represented a relevant scientific achievement in the organoid field. Importantly, hPSC-derived kidney organoids contain multiple nephron-like ...
Hydroxyapatite-based biphasic catalysts with plasticity properties and its potential in carbon dioxide fixation
The design of catalysts with controlled selectivity at will, also known as catalytic plasticity, is a very attractive approach for the recycling of carbon dioxide (CO2). In this work, we study how catalytically active ...
Size Effect of Silver Nanoparticles Derived from Olive Mill Wastewater in THP-1 Cell Lines
The constant demand of silver nanoparticles (AgNPs) for different applications requires a new selection of solvents and reagents for their synthesis, to make them less toxic to living organisms and the environment. Among ...
Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
This study explored the use of parasternal second intercostal space and lower intercostal space surface electromyogram (sEMG) and surface mechanomyogram (sMMG) recordings (sEMGpara and sMMGpara, and sEMGlic and sMMGlic, ...
Mapping the relationship between total and functional antibodies conjugated to nanoparticles with spectrally-resolved direct stochastic optical reconstruction microscopy (SR-dSTORM)
Antibody-functionalized nanoparticles (NPs) have shown numerous benefits in drug delivery and biosensing, improving the specificity of cell targeting and analyte detection, respectively. However, one of the main challenges ...
Organs-on-Chips: Trends and Challenges in Advanced Systems Integration
Organ-on-chip platforms combined with high-throughput sensing technology allow bridging gaps in information presented by 2D cultures modeled on static microphysiological systems. While these platforms do not aim to replicate ...
Detection of Sleep-Disordered Breathing in Patients with Spinal Cord Injury Using a Smartphone
Patients with spinal cord injury (SCI) have an increased risk of sleep-disordered breathing (SDB), which can lead to serious comorbidities and impact patients’ recovery and quality of life. However, sleep tests are rarely ...
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward-motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of ...
Core-shell microspheres for the ultrafast degradation of estrogen hormone at neutral pH
In the past few years there has been growing concern about human exposure to endocrine disrupting chemicals. This kind of pollutants can bioaccumulate in aquatic organisms and lead to serious health problems, especially ...
Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics
A hallmark of cancer is cell death evasion, underlying suboptimal responses to chemotherapy, targeted agents, and immunotherapies. The approval of the anti apoptotic BCL2 antagonist venetoclax has fi nally validated the ...
Lipase-Powered Mesoporous Silica Nanomotors for Triglyceride Degradation
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We report lipase-based nanomotors that are capable of enhanced Brownian motion over long periods of time in triglyceride solution and of degrading triglyceride droplets ...
Xeno-free bioengineered human skeletal muscle tissue using human platelet lysate-based hydrogels
Bioengineered human skeletal muscle tissues have emerged in the last years as new in vitro systems for disease modeling. These bioartificial muscles are classically fabricated by encapsulating human myogenic precursor cells ...
Green Silver Nanoparticles Promote Inflammation Shutdown in Human Leukemic Monocytes
The use of silver nanoparticles (Ag NPs) in the biomedical field deserves a mindful analysis of the possible inflammatory response which could limit their use in the clinic. Despite the anti-cancer properties of Ag NPs ...
Control of Mechanotransduction by Molecular Clutch Dynamics
By considering the molecular and mechanical properties of actin filaments, myosin motors, adaptor proteins, and integrins/cadherins, the molecular clutch model can quantitatively predict cell response to internal and ...
