Institut de Bioenginyeria de Catalunya (IBEC): Enviaments recents
Ara mostrant els elements 41-60 de 656
Enzymatic micro/nanomotors in biomedicine: from single motors to swarms
Micro/nanomotors (MNMs) have evolved from single self-propelled entities to versatile systems capable of performing one or multiple biomedical tasks. When single MNMs self-assemble into coordinated swarms, either under ...
Rational Design of Photochromic Analogues of Tricyclic Drugs
Tricyclic chemical structures are the core of many important drugs targeting all neurotransmitter pathways. These medicines enable effective therapies to treat from peptic ulcer disease to psychiatric disorders. However, ...
Lipidic lyotropic liquid crystals: Insights on biomedical applications
Liquid crystals (LCs) possess unique physicochemical properties, translatable into a wide range of applications. To date, lipidic lyotropic LCs (LLCs) have been extensively explored in drug delivery and imaging owing to ...
Erythrina velutina Willd. alkaloids: Piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves
Introduction: Natural products of pharmaceutical interest often do not reach the drug market due to the associated low yields and difficult extraction. Knowledge of biosynthetic pathways is a key element in the development ...
Differences in acoustic features of cough by pneumonia severity in patients with COVID-19: a cross-sectional study
BackgroundAcute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) is characterised by heterogeneous levels of disease severity. It is not necessarily apparent whether a patient will develop a severe disease or not. ...
Correlating comprehensive two-dimensional gas chromatography volatile profiles of chocolate with sensory analysis
The identification of key components relevant to sensory perception of quality from commercial chocolate samples was accomplished after chemometric processing of GC×GC-MS (Comprehensive Two-dimensional Gas Chromatography ...
Principles for the design of multicellular engineered living systems
Remarkable progress in bioengineering over the past two decades has enabled the formulation of fundamental design principles for a variety of medical and non-medical applications. These advancements have laid the foundation ...
The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations
Plaques of the amyloid beta (Aβ) peptide are a pathological hallmark of Alzheimer's Disease (AD), the most common form of dementia. Mutations in Aβ also cause familial forms of AD (fAD). Here we use deep mutational scanning ...
Light-Activated Pharmacological Tools for Exploring the Cholinergic System
Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor ...
Sleeppos app: An automated smartphone application for angle based high resolution sleep position monitoring and treatment
Poor sleep quality or disturbed sleep is associated with multiple health conditions. Sleep position affects the severity and occurrence of these complications, and positional therapy is one of the less invasive treatments ...
Urease-powered nanomotor containing STING agonist for bladder cancer immunotherapy
Most non-muscle invasive bladder cancers have been treated by transurethral resection and following intravesical injection of immunotherapeutic agents. However, the delivery efficiency of therapeutic agents into bladder ...
Diagnosis of patients with chronic heart failure implementing wavelet transform and machine learning techniques
Chronic heart failure (CHF) is a significant public health concern due to its increasing prevalence, high number of hospital admissions, and associated mortality. Its prevalence is progressively increasing due to the aging ...
3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes
Three-dimensional engineering of skeletal muscle is becoming increasingly relevant for tissue engineering, disease modeling and bio-hybrid robotics, where flexible, versatile and multidisciplinary approaches for the ...
Nanomechanics of cell-derived matrices as a functional read-out in collagen VI-related congenital muscular dystrophies
Changes in the mechanical properties of the extracellular matrix (ECM) are a hallmark of disease. Due to its relevance, several in vitro models have been developed for the ECM, including cell-derived matrices (CDMs). CDMs ...
Nanoscale Mapping of Recombinant Viral Proteins: From Cells to Virus-Like Particles
Influenza recombinant proteins and virus-like particles (VLPs) play an important role in vaccine development (e.g., CadiFluS). However, their production from mammalian cells suffers from low yields and lack of control of ...
Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous ...
Optical Control of GABAA Receptors with a Fulgimide-Based Potentiator
Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of ...
Mycobacteria emulsified in olive oil-in-water trigger a robust immune response in bladder cancer treatment
The hydrophobic composition of mycobacterial cell walls leads to the formation of clumps when attempting to resuspend mycobacteria in aqueous solutions. Such aggregation may interfere in the mycobacteria-host cells interaction ...
Extubating of a patient undergoing mechanical ventilation: What is the right time? A retrospective study assisted by artificial intelligence techniques
In the presence of acute respiratory failure, mechanical ventilation emerges as a temporary alternative to maintain adequate gas exchange in the body such as that which occurs in natural respiration. This technique is ...
