Institut de Recerca Biomèdica (IRB Barcelona): Recent submissions
Now showing items 121-140 of 419
pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs
We study here a DNA oligonucleotide having the ability to form two different i-motif structures whose relative stability depends on pH and temperature. The major species at neutral pH is stabilized by two C:C+ base pairs ...
The ciliary impact of nonciliary gene mutations
Mutations in genes encoding centriolar or ciliary proteins cause diseases collectively known as ‘ciliopathies’. Interestingly, the Human Phenotype Ontology database lists numerous disorders that display clinical features ...
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Aneuploidy, an unbalanced number of chromosomes, is highly deleterious at the cellular level and leads to senescence, a stress-induced response characterized by permanent cell-cycle arrest and a well-defined associated ...
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Most patients with colorectal cancer die as a result of the disease spreading to other organs. However, no prevalent mutations have been associated with metastatic colorectal cancers1,2. Instead, particular features of the ...
Overcoming TGFβ-mediated immune evasion in cancer
This Review discusses the context-dependent functions of transforming growth factor-beta (TGF beta) with regard to the composition and behaviour of different cell populations in the tumour immune microenvironment, as well ...
The lysosomal proteome of senescent cells contributes to the senescence secretome
Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age-related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity. Here, ...
Basal association of a transcription factor favors early gene expression
Responses to extracellular signals via Mitogen-Activated Protein Kinase (MAPK) pathways control complex transcriptional programs where hundreds of genes are induced at a desired level with a specific timing. Gene expression ...
Five latent factors underlie response to immunotherapy
Only a subset of patients treated with immune checkpoint inhibitors (CPIs) respond to the treatment, and distinguishing responders from non-responders is a major challenge. Many proposed biomarkers of CPI response and ...
Quantification of pathway crosstalk reveals novel synergistic drug combinations for breast cancer
Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently ...
GEMC1 is a critical regulator of multiciliated cell differentiation
The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass ...
On the impact of incomplete taxon sampling on the relative timing of gene transfer events
A recent study questioned the use of branch length methods to assess the relative timing of horizontal gene transfers because of the effects of so-called "ghost" lineages. This Formal Comment discusses key considerations ...
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress
Tumor growth is influenced by a complex network of interactions between multiple cell types in the tumor microenvironment (TME). These constrained conditions trigger the endoplasmic reticulum (ER) stress response, which ...
Cancer stem cells revisited
© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is ...
Control of cell adhesion and compartmentalization in the intestinal epithelium
Continuous cell renewal in the intestinal mucosa occurs without disrupting the integrity of the epithelial layer. Despite the restrictions imposed by strong cell-to-cell adhesions, epithelial intestinal cells migrate ...
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation
A disordered to β-sheet transition was thought to drive the functional switch of Q/N-rich prions, similar to pathogenic amyloids. However, recent evidence indicates a critical role for coiled-coil (CC) regions within yeast ...
A novel redox cycle diverts cells from oncogene-induced senescence into cancer
Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether ...
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the ...
Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals
BackgroundNonsense-mediated mRNA decay (NMD) is a quality-control pathway that degrades mRNA bearing premature termination codons (PTCs) resulting from mutation or mis-splicing, and that additionally participates in gene ...
Chasing molecular glue degraders: screening approaches
Protein-protein interactions (PPIs) govern all biological processes. Some small molecules modulate PPIs through induced protein proximity. In particular, molecular glue degraders are monovalent compounds that orchestrate ...
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral ...
